Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 222, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2022.113046
Keywords
Sulfonated hyaluronic acid; Sulfur content; Cytocompatibility; Blood compatibility
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This study successfully obtained two kinds of sulfonated hyaluronic acid (S-HA) with higher sulfur content. Through a series of cell experiments, it was found that the S-HA with higher sulfur content not only possessed stronger ability in promoting endothelial cell growth and migration, regulating smooth muscle cell phenotype, but also had stronger anti-inflammatory function. Furthermore, all the S-HA molecules are highly compatible with blood.
Sulfonated hyaluronic acid (S-HA) has been shown to promote endothelialization in the treatment of cardiovascular diseases according to amounts of investigations. In this study, two kinds of S-HA with higher sulfur content were obtained successfully. Through a series of cell experiments, it was found that the S-HA with higher sulfur content not only possessed stronger ability of promoting the growth and migration of endothelial cells, regulating the phenotype of smooth muscle cells, but also had stronger anti-inflammatory function. Furthermore, all the S-HA molecules are very compatible with blood.
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