Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 222, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.colsurfb.2022.113029
Keywords
Osteoporosis treatment; Curcumin; Poly(amidoamine) dendrimers; Drug delivery system
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Osteoporosis is an age-related metabolic disease that causes bone pain and fragility fractures. This study developed a novel method to conjugate curcumin with poly(amidoamine) dendrimers using hexachlorocyclotriphosphazene as a linker, forming stable and uniform curcumin-loaded nanospheres. The nanoparticles showed excellent water dispersity and pH-responsive drug release, and demonstrated dual effects of inhibiting osteoclasts and promoting osteoblasts for the treatment of osteoporosis.
Osteoporosis is an age-related metabolic disease of bone, resulting in bone pain and even bone fragility and brittle fracture. Inhibiting overactive osteoclasts while promoting osteoblast activity is an ideal way to treat osteoporosis. Previous studies have demonstrated that natural compounds, such as curcumin (Cur) have dual roles both in promoting bone formation and inhibiting bone resorption, making them promising candidates for osteoporosis treatment. However, their poor water solubility, high dosage of curative effect and significant toxicity to other organs have largely limited their clinical translations. In this study, a novel method was reported to conjugate Cur and poly(amidoamine) dendrimers (PAD) using hexachlorocyclotriphosphazene (HCCP) as the linkage through a one-pot reaction, forming stable and uniform Cur loaded nanospheres (HCCP-Cur-PAD, HCP NPs). Owing to the hydrophilicity of PAD and hydrophobicity of Cur, HCP NPs can self-assemble into nanoparticles with particle size of 138.8 & PLUSMN; 78.7 nm and display excellent water dispersity. The loading capacity of Cur can reach 27.2% and it can be released from HCP NPs with pH-responsiveness. In vitro experimental results demonstrated that the HCP NPs entered lysosomes by endocytosis and proved dual anti-osteoporosis effects of inhibiting osteoclasts and promoting osteoblasts.
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