4.7 Article

Interaction of new VV-hemorphin-5 analogues with cell membrane models

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Investigation of the structure-activity relationship in a series of new LVV- and VV-hemorphin-7 analogues designed as potential anticonvulsant agents

Petar Todorov et al.

Summary: In this study, new analogues of LVV- and VV-hemorphin-7 were synthesized and characterized. Modifications were made at the N- and C-terminus to optimize their physicochemical properties and anticonvulsant potency. The structure-property relationship of the peptide analogues was studied, and their lipophilicity was presented. The anticonvulsant activity of the analogues was explored, and their potential neurological toxicity was checked. The results suggest that modifications at the N- and C-terminus of certain amino acids in the hemorphin analogues play a crucial role in designing new LVV- and VV-hemorphin-7 analogues.

AMINO ACIDS (2022)

Article Multidisciplinary Sciences

Valorphins alter physicochemical characteristics of phosphatidylcholine membranes: Datasets on lipid packing, bending rigidity, specific electrical capacitance, dipole potential, vesicle size

Victoria Vitkova et al.

Summary: This study investigates the potential therapeutic use of endogenous hemorphins, as well as their role as biomarkers in mood regulation, inflammation, and oncology. The collected datasets provide information on the physical and chemical properties of membranes in the presence of VV-hemorphin-5 and its analogues, shedding light on their interactions and effects.

DATA IN BRIEF (2022)

Article Chemistry, Multidisciplinary

Superelasticity of Plasma- and Synthetic Membranes Resulting from Coupling of Membrane Asymmetry, Curvature, and Lipid Sorting

Jan Steinkuehler et al.

Summary: By preserving the structure and composition of the plasma membrane during isolation, vesicles with cell-like elasticity can be obtained, storing significant area in the form of nanotubes and lipid reservoirs. The interplay of lipid domains and membrane curvature leads to a superelastic response that allows for engineering synthetic biomaterials with enhanced deformability.

ADVANCED SCIENCE (2021)

Review Biochemistry & Molecular Biology

Surface Characterization of Lipid Biomimetic Systems

Anibal Disalvo et al.

Summary: Zeta potential and dipole potential measurements are direct methodologies for determining the adsorption, insertion, and penetration of compounds into cell membranes, contributing to an understanding of charged and dipole groups. The correlation between dipole and zeta potential influences the responsiveness of membranes and the propagation of disturbances within complex systems.

MEMBRANES (2021)

Article Biochemistry & Molecular Biology

Dielectric Properties of Phosphatidylcholine Membranes and the Effect of Sugars

Victoria Vitkova et al.

Summary: The study investigated the effects of monosaccharides and disaccharides on biomimetic lipid systems, focusing on dielectric properties, hydration levels, and lipid bilayer properties. Glucose and fructose were found to preserve membrane dielectric properties, while sucrose altered membrane specific capacitance. The results provide insights for future developments in lipid bilayer response to external stimuli.

MEMBRANES (2021)

Review Biochemistry & Molecular Biology

Hemorphins-From Discovery to Functions and Pharmacology

Przemyslaw Mielczarek et al.

Summary: This review summarizes the current state-of-the-art regarding hemorphins, their methodological aspects of identification, and their potential therapeutic role. It covers a wide spectrum of characteristics and applications, combining analytical and pharmacological aspects of peptides described by a team who participated in the initial research on hemorphins.

MOLECULES (2021)

Review Biochemistry & Molecular Biology

Hemoglobin-derived peptides and mood regulation

Fengmei Wei et al.

PEPTIDES (2020)

Review Pharmacology & Pharmacy

Molecular basis of the therapeutic properties of hemorphins

Amanat Ali et al.

PHARMACOLOGICAL RESEARCH (2020)

Article Chemistry, Medicinal

Anticonvulsant evaluation and docking analysis of VV-Hemorphin-5 analogues

Petar Todorov et al.

DRUG DEVELOPMENT RESEARCH (2019)

Review Geriatrics & Gerontology

Involvement of hemoglobins in the pathophysiology of Alzheimer's disease

Meric A. Altinoz et al.

EXPERIMENTAL GERONTOLOGY (2019)

Article Chemistry, Physical

Unraveling the Origin of the Apparent Charge of Zwitterionic Lipid Layers

Lisa B. Dreier et al.

JOURNAL OF PHYSICAL CHEMISTRY LETTERS (2019)

Article Physics, Fluids & Plasmas

Membrane-mediated interaction of amphipathic peptides can be described by a one-dimensional approach

Oleg V. Kondrashov et al.

PHYSICAL REVIEW E (2019)

Article Biochemistry & Molecular Biology

Therapeutic peptides: Historical perspectives, current development trends, and future directions

Jolene L. Lau et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2018)

Article Chemistry, Physical

Sucrose solutions alter the electric capacitance and dielectric permittivity of lipid bilayers

Victoria Vitkova et al.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2018)

Article Chemistry, Medicinal

Synthesis, characterization and nociceptive screening of new VV-hemorphin-5 analogues

Petar Todorov et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2018)

Article Physics, Fluids & Plasmas

Registration and analysis of the shape fluctuations of nearly spherical lipid vesicles

Julia Genova et al.

PHYSICAL REVIEW E (2013)

Article Chemistry, Multidisciplinary

Inverse-Phosphocholine Lipids: A Remix of a Common Phospholipid

Emily K. Perttu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

Article Chemistry, Physical

Electrodeformation method for measuring the capacitance of bilayer membranes

Paul F. Salipante et al.

SOFT MATTER (2012)

Article Chemistry, Multidisciplinary

Interactions of Alkali Metal Chlorides with Phosphatidylcholine Vesicles

Benjamin Klasczyk et al.

LANGMUIR (2010)

Article Biophysics

Electrohydrodynamic Model of Vesicle Deformation in Alternating Electric Fields

Petia M. Vlahovska et al.

BIOPHYSICAL JOURNAL (2009)

Article Biophysics

Effect of headgroup on the dipole potential of phospholipid vesicles

Thomas Starke-Peterkovic et al.

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS (2009)

Article Chemistry, Physical

Measurement and interpretation of electrokinetic phenomena

A. V. Delgado et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2007)

Article Biophysics

Alamethicin influence on the membrane bending elasticity

V Vitkova et al.

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS (2006)

Article Physics, Fluids & Plasmas

Bending elasticity and bending fluctuations of lipid bilayer containing an additive

I Bivas et al.

PHYSICAL REVIEW E (2003)