Abnormal brain functional network dynamics in sleep-related hypermotor epilepsy

AimsThis study aimed to use resting-state functional magnetic resonance imaging (rs-fMRI) to determine the temporal features of functional connectivity states and changes in connectivity strength in sleep-related hypermotor epilepsy (SHE). MethodsHigh-resolution T1 and rs-fMRI scanning were performed on all the subjects. We used a sliding-window approach to construct a dynamic functional connectivity (dFC) network. The k-means clustering method was performed to analyze specific FC states and related temporal properties. Finally, the connectivity strength between the components was analyzed using network-based statistics (NBS) analysis. The correlations between the abovementioned measures and disease duration were analyzed. ResultsAfter k-means clustering, the SHE patients mainly exhibited two dFC states. The frequency of state 1 was higher, which was characterized by stronger connections within the networks; state 2 occurred at a relatively low frequency, characterized by stronger connections between networks. SHE patients had greater fractional time and a mean dwell time in state 2 and had a larger number of state transitions. The NBS results showed that SHE patients had increased connectivity strength between networks. None of the properties was correlated with illness duration among patients with SHE. ConclusionThe patterns of dFC patterns may represent an adaptive and protective mode of the brain to deal with epileptic seizures.

Automated summary

This study used rs-fMRI to investigate the temporal features of functional connectivity states and changes in connectivity strength in sleep-related hypermotor epilepsy (SHE). The results showed that SHE patients exhibited two dFC states, with state 1 characterized by stronger connections within networks and state 2 characterized by stronger connections between networks. SHE patients had increased fractional time and mean dwell time in state 2, as well as a higher number of state transitions. The NBS analysis revealed increased connectivity strength between networks in SHE patients. These findings suggest that the patterns of dFC may represent adaptive and protective mechanisms in the brain against epileptic seizures.