Ga-68-DOTANOC PET/CT in Adrenal Schwannoma

Adrenal schwannoma is a rare adrenal incidentaloma. It is a benign tumor arising from the Schwann cells. Differentiating benign from malignant adrenal lesions requires a combination of clinical, biochemical, imaging, and histopathological findings. Ga-68-DOTANOC PET/CT is one of the sensitive imaging modalities to detect adrenal lesions such as pheochromocytoma. Multiple benign and malignant lesions show somatostatin receptor expression causing a high probability of false-positive findings on somatostatin receptor imaging. We present a case of adrenal incidentaloma positive on Ga-68-DOTANOC PET, which revealed a benign adrenal spindle cell tumor on histopathology.

Automated summary

Adrenal schwannoma is a rare benign tumor arising from the Schwann cells, and differentiating it from malignant adrenal lesions requires a combination of clinical, biochemical, imaging, and histopathological findings. Ga-68-DOTANOC PET/CT is a sensitive imaging modality for detecting adrenal lesions like pheochromocytoma. However, false-positive findings on somatostatin receptor imaging are common due to the expression of somatostatin receptors in both benign and malignant lesions. Here, we present a case of adrenal incidentaloma that showed positive findings on Ga-68-DOTANOC PET, but was confirmed as a benign adrenal spindle cell tumor on histopathology.