4.6 Review

Osteoarticular Mycoses

Journal

CLINICAL MICROBIOLOGY REVIEWS
Volume 35, Issue 4, Pages -

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/cmr.00086-19

Keywords

mycoses; antifungal therapy; aspergillosis; candidiasis; coccidioidomycosis; cryptococcosis; histoplasmosis; mucormycosis; osteomyelitis; phaeohyphomycosis

Categories

Funding

  1. Save Our Sick Kids Foundation
  2. Henry Schueler 419 Foundation
  3. Intramural Research Program of the National Institutes of Health (NIH) Clinical Center

Ask authors/readers for more resources

Osteoarticular mycoses are chronic debilitating infections that require extended courses of antifungal therapy and may warrant expert surgical intervention. This review provides a comprehensive analysis of the etiologies, clinical manifestations, diagnostic approaches, treatments, and outcomes of these infections. Candida osteomyelitis and Candida arthritis are associated with greater events of hematogenous dissemination than other osteoarticular mycoses, while traumatic inoculation is more commonly linked with Aspergillus and non-Aspergillus molds.
Osteoarticular mycoses are chronic debilitating infections that require extended courses of antifungal therapy and may warrant expert surgical intervention. As there has been no comprehensive review of these diseases, the International Consortium for Osteoarticular Mycoses prepared a definitive treatise for this important class of infections. Among the etiologies of osteoarticular mycoses are Candida spp., Aspergillus spp., Mucorales, dematiaceous fungi, non-Aspergillus hyaline molds, and endemic mycoses, including those caused by Histoplasma capsulatum, Blastomyces dermatitidis, and Coccidioides species. This review analyzes the history, epidemiology, pathogenesis, clinical manifestations, diagnostic approaches, inflammatory biomarkers, diagnostic imaging modalities, treatments, and outcomes of osteomyelitis and septic arthritis caused by these organisms. Candida osteomyelitis and Candida arthritis are associated with greater events of hematogenous dissemination than those of most other osteoarticular mycoses. Traumatic inoculation is more commonly associated with osteoarticular mycoses caused by Aspergillus and non-Aspergillus molds. Synovial fluid cultures are highly sensitive in the detection of Candida and Aspergillus arthritis. Relapsed infection, particularly in Candida arthritis, may develop in relation to an inadequate duration of therapy. Overall mortality reflects survival from disseminated infection and underlying host factors. Osteoarticular mycoses are chronic debilitating infections that require extended courses of antifungal therapy and may warrant expert surgical intervention. As there has been no comprehensive review of these diseases, the International Consortium for Osteoarticular Mycoses prepared a definitive treatise for this important class of infections.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available