Journal
CLINICAL MICROBIOLOGY REVIEWS
Volume 35, Issue 4, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/cmr.00092-22
Keywords
Monkeypox virus; monkeypox; Orthopoxvirus; virology; outbreak; public health; immunization; tecovirimat
Categories
Ask authors/readers for more resources
This review discusses the origins and virology of human monkeypox, its connection with smallpox eradication, outbreaks in endemic and non-endemic regions, clinical manifestations, diagnostic methods, case management, public health interventions, and future directions.
Human monkeypox is a viral zoonosis endemic to West and Central Africa that has recently generated increased interest and concern on a global scale as an emerging infectious disease threat in the midst of the slowly relenting COVID-2019 disease pandemic. The hallmark of infection is the development of a flu-like prodrome followed by the appearance of a smallpox-like exanthem. Precipitous person-to-person transmission of the virus among residents of 100 countries where it is nonendemic has motivated the immediate and widespread implementation of public health countermeasures. In this review, we discuss the origins and virology of monkeypox virus, its link with smallpox eradication, its record of causing outbreaks of human disease in regions where it is endemic in wildlife, its association with outbreaks in areas where it is nonendemic, the clinical manifestations of disease, laboratory diagnostic methods, case management, public health interventions, and future directions. Human monkeypox is a viral zoonosis endemic to West and Central Africa that has recently generated increased interest and concern on a global scale as an emerging infectious disease threat in the midst of the slowly relenting COVID-2019 disease pandemic. The hallmark of infection is the development of a flu-like prodrome followed by the appearance of a smallpox-like exanthem.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available