4.7 Article

Association Between the Development of Subclinical Cardiovascular Disease and Human Immunodeficiency Virus (HIV) Reservoir Markers in People With HIV on Suppressive Antiretroviral Therapy

Journal

CLINICAL INFECTIOUS DISEASES
Volume 76, Issue 7, Pages 1318-1321

Publisher

OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciac874

Keywords

HIV reservoir; cardiovascular diseases; HIV DNA; atherosclerotic plaque; aging

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People with HIV diagnosed with atherosclerotic plaques have higher levels of HIV DNA compared to those without plaques. In a prediction model with 27 traditional and HIV-related risk factors, measures of HIV DNA were found to be among the most important predictors of plaque formation.
We report that people with human immunodeficiency virus (HIV) diagnosed with coronary artery atherosclerotic plaques display higher levels of HIV DNA compared with those without atherosclerotic plaques. In a multivariable prediction model that included 27 traditional and HIV-related risk factors, measures of HIV DNA were among the most important predictors of atherosclerotic plaque formation.

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