How is oral isotretinoin prescribed for the treatment of acne vulgaris? Results from a UK Dermatology Clinical Trials Network (UKDCTN) and British Dermatological Nursing Group (BDNG) survey of health professionals

We undertook a survey of UK healthcare professionals through the UK Dermatology Clinical Trials Network and British Dermatological Nursing Group to understand clinicians' routine practice of prescribing oral isotretinoin for treatment of acne vulgaris. We also wanted to understand clinicians' experiences and views on prescribing low daily dose regimens. Overall, the survey showed that clinicians adopted a patient-centred approach when deciding isotretinoin dosing. The rationale for using a low-dose regimen varied, but was focused on patient wellbeing during treatment. Some clinicians were concerned that use of a low-dose regimen could be less effective and lead to longer treatment durations. The survey results will be useful to inform a clinical trial investigating the effectiveness and safety of low daily dose isotretinoin for the treatment of acne. This study focuses on clinicians' views about prescribing low-dose oral isotretinoin regimens. The systematic review informing the National Insitute for Health and Care Excellence guideline NG198 found that evidence for a lower daily dose of isotretinoin was scarce, with results derived almost exclusively from trials testing at least 0 center dot 5 mg kg(-1) daily, highlighting the need for further research. The results of this survey will be useful to inform a clinical trial.

Automated summary

We conducted a survey to understand UK healthcare professionals' routine practice of prescribing oral isotretinoin for acne vulgaris treatment and their experiences and views on low daily dose regimens. The survey showed that clinicians adopted a patient-centred approach in dosing decisions, with varied rationales for using low-dose regimens focused on patient wellbeing. Concerns about efficacy and treatment duration were also noted. The survey results will inform a clinical trial investigating the effectiveness of low daily dose isotretinoin for acne treatment.