4.8 Article

ATIC-Associated De Novo Purine Synthesis Is Critically Involved in Proliferative Arterial Disease

Related references

Note: Only part of the references are listed.
Article Oncology

HPRT promotes proliferation and metastasis in head and neck squamous cell carcinoma through direct interaction with STAT3

Lin Wang et al.

Summary: A study showed that higher HPRT expression in HNSCC tissue is associated with poor prognosis, and overexpression of HPRT can increase the expression of EMT markers by interacting with STAT3. Knocking down HPRT significantly inhibits tumor growth and enhances the anticancer effect of EGFR inhibitors against HNSCC xenografts.

EXPERIMENTAL CELL RESEARCH (2021)

Article Biochemistry & Molecular Biology

Modulation of adenine phosphoribosyltransferase-mediated salvage pathway to accelerate diabetic wound healing

Guang-Huar Young et al.

Summary: The study demonstrates that APRT plays a crucial role in skin wound healing by regulating the nucleotide pool after injury. Adenine treatment can increase ATP levels, promote wound healing, and provide necessary adenylate for ATP generation.

FASEB JOURNAL (2021)

Review Biochemistry & Molecular Biology

Human de novo purine biosynthesis

Vidhi Pareek et al.

Summary: This review highlights the human de novo purine biosynthetic pathway, discussing the assembly and function of purinosomes, as well as potential signaling pathways that regulate their formation and disassembly. The findings support the existence of a metabolon and suggest insights into how other metabolic pathways may be organized for optimal function.

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2021)

Article Immunology

Targeting CLK3 inhibits the progression of cholangiocarcinoma by reprogramming nucleotide metabolism

Qingxin Zhou et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

Review Rheumatology

Methotrexate mechanism in treatment of rheumatoid arthritis

Benjamin Friedman et al.

JOINT BONE SPINE (2019)

Review Cell Biology

Metabolic regulation of cell growth and proliferation

Jiajun Zhu et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Review Biochemistry & Molecular Biology

The microRNAs Regulating Vascular Smooth Muscle Cell Proliferation: A Minireview

Dongdong Wang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Neurosciences

Purine synthesis promotes maintenance of brain tumor initiating cells in glioma

Xiuxing Wang et al.

NATURE NEUROSCIENCE (2017)

Review Biochemistry & Molecular Biology

A New View into the Regulation of Purine Metabolism: The Purinosome

Anthony M. Pedley et al.

TRENDS IN BIOCHEMICAL SCIENCES (2017)

Article Cell Biology

Purine Nucleotide Availability Regulates mTORC1 Activity through the Rheb GTPase

Natasha Emmanuel et al.

CELL REPORTS (2017)

Article Cardiac & Cardiovascular Systems

Intracoronary Brachytherapy for Recurrent Drug-Eluting Stent Failure

Smita I. Negi et al.

JACC-CARDIOVASCULAR INTERVENTIONS (2016)

Article Multidisciplinary Sciences

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

Issam Ben-Sahra et al.

SCIENCE (2016)

Article Biochemistry & Molecular Biology

AMPK Activation via Modulation of De Novo Purine Biosynthesis with an Inhibitor of ATIC Homodimerization

Daniel J. Asby et al.

CHEMISTRY & BIOLOGY (2015)

Article Biochemistry & Molecular Biology

Regulation of mammalian nucleotide metabolism and biosynthesis

Andrew N. Lane et al.

NUCLEIC ACIDS RESEARCH (2015)

Article Endocrinology & Metabolism

Methotrexate Promotes Glucose Uptake and Lipid Oxidation in Skeletal Muscle via AMPK Activation

Sergej Pirkmajer et al.

DIABETES (2015)

Article Oncology

Pemetrexed Indirectly Activates the Metabolic Kinase AMPK in Human Carcinomas

Scott B. Rothbart et al.

CANCER RESEARCH (2010)

Review Cell Biology

The molecular determinants of de novo nucleotide biosynthesis in cancer cells

Xuemei Tong et al.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2009)

Article Multidisciplinary Sciences

Genome-wide transcriptional analysis of the human cell cycle identifies genes differentially regulated in normal and cancer cells

Ziv Bar-Joseph et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Review Biochemistry & Molecular Biology

Vascular proliferation and atherosclerosis: New perspectives and therapeutic strategies

VJ Dzau et al.

NATURE MEDICINE (2002)

Review Rheumatology

Molecular action of methotrexate in inflammatory diseases

ESL Chan et al.

ARTHRITIS RESEARCH (2002)

Article Biochemistry & Molecular Biology

Glucose exerts a permissive effect on the regulation of the initiation factor 4E binding protein 4E-BP1

J Patel et al.

BIOCHEMICAL JOURNAL (2001)

Article Biochemistry & Molecular Biology

The rate of cell growth is regulated by purine biosynthesis via ATP production and G1 to S phase transition

M Kondo et al.

JOURNAL OF BIOCHEMISTRY (2000)