Single Molecule Imaging with Liquid Phase Electron Microscopy

Article Chemistry, Multidisciplinary

Conformation Dynamics of Single Polymer Strands in Solution

Yuna Bae et al.

Summary: This paper utilizes liquid-phase transmission electron microscopy to track the real-time dynamics of single-chain polymers, revealing the conformational characteristics of these polymers and their dependence on intrachain interactions and environmental factors.

ADVANCED MATERIALS (2022)

Add to Collection

Article Multidisciplinary Sciences

Tracking single adatoms in liquid in a transmission electron microscope

Nick Clark et al.

Summary: Single atoms or ions on surfaces have an impact on various processes. Transmission electron microscopy is a leading method for observing single atoms. Graphene liquid cells enable atomic-resolution imaging in liquids.

NATURE (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Dipeptide Nanostructure Assembly and Dynamics via in Situ Liquid-Phase Electron Microscopy

Karthikeyan Gnanasekaran et al.

Summary: This study reports the in situ growth of FF nanotubes examined via liquid-cell transmission electron microscopy (LCTEM), revealing the growth mechanism and structure formation process. The radial growth profile of the nanotubes was observed in real-time, with direct observation of the increase in diameter. Post-mortem techniques were used to verify and evaluate the performance of peptides and the assemblies they form.

ACS NANO (2021)

Add to Collection

Article Cell Biology

Quantification of EGFR-HER2 Heterodimers in HER2-Overexpressing Breast Cancer Cells Using Liquid-Phase Electron Microscopy

Diana B. Peckys et al.

Summary: The study revealed subcellular heterogeneity in receptor distribution on the plasma membrane of HER2 overexpressing breast cancer cells, indicating differences in dynamic properties. By combining quantum dot labeling with quantitative, correlative light and liquid-phase electron microscopy, single-cell data on EGFR and HER2 receptor density, dimer percentages, and their heterogeneities were obtained, providing potential insights for early identification of patients with increased risk for drug resistance.

CELLS (2021)

Add to Collection

Article Multidisciplinary Sciences