4.7 Article

A tetrahedral framework nucleic acid based multifunctional nanocapsule for tumor prophylactic mRNA vaccination

Related references

Note: Only part of the references are listed.
Article Engineering, Biomedical

Tetrahedral framework nucleic acids-based delivery of microRNA-155 inhibits choroidal neovascularization by regulating the polarization of macrophages

Xin Qin et al.

Summary: In this study, we developed a new DNA-based drug called T-155, which improved the symptoms of choroidal neovascularization by regulating the polarization of macrophages.

BIOACTIVE MATERIALS (2022)

Article Engineering, Biomedical

Anti-inflammatory activity of curcumin-loaded tetrahedral framework nucleic acids on acute gouty arthritis

Mei Zhang et al.

Summary: Gouty arthritis is a common inflammatory arthritis, and controlling inflammation is crucial for prevention. Scientists have synthesized a new material called Cur-TFNAs to enhance the effectiveness and bioavailability of curcumin, a natural anti-inflammatory drug. Cur-TFNAs showed better anti-inflammatory effects in in vivo and in vitro experiments compared with free curcumin.

BIOACTIVE MATERIALS (2022)

Article Chemistry, Multidisciplinary

Antiepilepticus Effects of Tetrahedral Framework Nucleic Acid via Inhibition of Gliosis-Induced Downregulation of Glutamine Synthetase and Increased AMPAR Internalization in the Postsynaptic Membrane

Jianwei Zhu et al.

Summary: Nanomaterial tFNA shows potential as an antiepileptic drug by crossing the blood-brain barrier, reducing inflammation and neuronal hyperexcitability in mice, and may provide a new direction for epilepsy treatment.

NANO LETTERS (2022)

Review Biotechnology & Applied Microbiology

The clinical progress of mRNA vaccines and immunotherapies

Ann J. Barbier et al.

Summary: The emergency use authorizations (EUAs) of mRNA-based vaccines against SARS-CoV-2 highlight the transformative potential of this nucleic acid technology. Clinical applications of mRNA have mainly focused on vaccines for infectious diseases and cancer, but there are challenges in using mRNA for immunotherapies. The past year has seen significant progress in the clinical development of mRNA therapies for COVID-19, as well as other diseases such as influenza, HIV, and cancer.

NATURE BIOTECHNOLOGY (2022)

Article Chemistry, Physical

A DNA nanodevice-based vaccine for cancer immunotherapy

Shaoli Liu et al.

Summary: A DNA nanodevice vaccine has been developed to stimulate a tumor-specific cytotoxic T lymphocyte response, leading to inhibition of tumor growth and prevention of metastasis. The vaccine utilizes molecular adjuvants and antigen peptides within a tubular DNA nanostructure to trigger T-cell activation and cancer cytotoxicity, showing promising results in mouse cancer models. The vaccination generates long-term T-cell responses which effectively protect against tumor rechallenge.

NATURE MATERIALS (2021)

Review Engineering, Biomedical

Nanobiomaterial-based vaccination immunotherapy of cancer

Fangmin Chen et al.

Summary: Cancer vaccines, including antigen peptide/adjuvant-based nanovaccines, nucleic acid-based nanovaccines, and biomimetic nanobiomaterials-based nanovaccines, have shown significant efficacy in inhibiting tumor growth and preventing relapse and metastasis. However, challenges remain in the clinical translation of these vaccines. The use of various nanobiomaterials has great potential to enhance the efficacy of cancer vaccines and reduce off-target effects.

BIOMATERIALS (2021)

Review Nanoscience & Nanotechnology

The current landscape of nucleic acid therapeutics

Jayesh A. Kulkarni et al.

Summary: The increasing number of approved nucleic acid therapeutics demonstrates their potential for long-lasting or curative effects by targeting genetic blueprints; however, their clinical translation relies on advances in delivery technologies. Four platform technologies, including antisense oligonucleotides, small interfering RNA conjugates, lipid nanoparticles, and adeno-associated virus vectors, have enabled the clinical translation of nucleic acid therapeutics, leading to the approval of cutting-edge genetic drugs.

NATURE NANOTECHNOLOGY (2021)

Review Nanoscience & Nanotechnology

Lipid nanoparticles for mRNA delivery

Xucheng Hou et al.

Summary: Lipid nanoparticle-mRNA formulations have successfully entered clinical use as COVID-19 vaccines, representing a major milestone in mRNA therapeutics. This review discusses the design of lipid nanoparticles for mRNA delivery, emphasizing key points for clinical translation and preclinical studies of lipid nanoparticle-mRNA therapeutics for various diseases.

NATURE REVIEWS MATERIALS (2021)

Article Biochemical Research Methods

Stimuli-Responsive Conformational Transformation of Peptides for Tunable Cytotoxicity

Jeonghun Lee et al.

BIOCONJUGATE CHEMISTRY (2020)

Review Biotechnology & Applied Microbiology

Antimicrobial host defence peptides: functions and clinical potential

Neeloffer Mookherjee et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

Review Pharmacology & Pharmacy

Engineered Nanodelivery Systems to Improve DNA Vaccine Technologies

Michael Lim et al.

PHARMACEUTICS (2020)

Article Medicine, Research & Experimental

Nanoparticles versus Dendritic Cells as Vehicles to Deliver mRNA Encoding Multiple Epitopes for Immunotherapy

Rebuma Firdessa-Fite et al.

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2020)

Review Oncology

The changing landscape of cancer in the USA - opportunities for advancing prevention and treatment

Farhad Islami et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

Article Medicine, General & Internal

An mRNA Vaccine against SARS-CoV-2-Preliminary Report

L. A. Jackson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Multidisciplinary Sciences

Prophylactic TNF blockade uncouples efficacy and toxicity in dual CTLA-4 and PD-1 immunotherapy

Elisabeth Perez-Ruiz et al.

NATURE (2019)

Article Chemistry, Multidisciplinary

Programming Drug Delivery Kinetics for Active Burst Release with DNA Toehold Switches

Mingshu Xiao et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

Article Chemistry, Multidisciplinary

Hybrid nanovaccine for the co-delivery of the mRNA antigen and adjuvant

Jingnan Yang et al.

NANOSCALE (2019)

Article Immunology

Mouse β-defensin-14 for inducing the maturation of dendritic cells

Xiangwei Yuan et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2018)

Review Chemistry, Physical

Recent advances in mRNA vaccine delivery

Lu Tan et al.

NANO RESEARCH (2018)

Review Biotechnology & Applied Microbiology

mRNA vaccines - a new era in vaccinology

Norbert Pardi et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

Article Nanoscience & Nanotechnology

A STING-activating nanovaccine for cancer immunotherapy

Min Luo et al.

NATURE NANOTECHNOLOGY (2017)

Review Nanoscience & Nanotechnology

Tools for translation: non-viral materials for therapeutic mRNA delivery

Khalid A. Hajj et al.

NATURE REVIEWS MATERIALS (2017)

Article Multidisciplinary Sciences

Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose

Jasdave S. Chahal et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Review Immunology

Host defense peptides: front-line immunomodulators

Sarah C. Mansour et al.

TRENDS IN IMMUNOLOGY (2014)

Article Biochemistry & Molecular Biology

Immune modulation by multifaceted cationic host defense (antimicrobial) peptides

Ashley L. Hilchie et al.

NATURE CHEMICAL BIOLOGY (2013)

Article Multidisciplinary Sciences

Toll-like receptor 4-dependent activation of dendritic cells by β-defensin 2

A Biragyn et al.

SCIENCE (2002)