Powerful and fast nanostructure electrochemical sensor for monitoring of carbidopa catechol-based drug in water and biological fluids

Herein, to monitor the concentration of carbidopa in an aqueous solution, an analytical approach based on electrode surface modification by Pt/SWCNTs as a sensor has been proposed. Pt/SWCNTs was synthesized by polyol strategy and characterized by the TEM method. Results confirmed spherical Pt nanoparticles with a diameter of about 10 nm decorated at the surface of SWCNTs with good distribution. The carbon paste electrode modified (CPEM) with Pt/SWCNTs was fabricated by mixing 12% of nanocomposite as an optimum condition with graphite powder in the presence of paraffin oil as a binder. Carbidopa's oxidation signal was enhanced by about 2.73 times when using the CPEM/Pt/SWCNTs, and its oxidation potential was decreased by about 110 mV. Additionally, the sensor demonstrated a linear dynamic range of 1.0 nM-120 M with a detection limit of 0.5 nM at pH = 7.0 as the ideal condition for monitoring carbidopa. Therefore, carbidopa in water and dextrose saline can be detected using CPEM/Pt/SWCNTs with an acceptable recovery range.

Automated summary

In this study, an analytical approach based on electrode surface modification by Pt/SWCNTs as a sensor was proposed to monitor the concentration of carbidopa in an aqueous solution. Pt/SWCNTs nanocomposite was synthesized using a polyol strategy and characterized by TEM. The carbon paste electrode modified with Pt/SWCNTs showed enhanced oxidation signal and decreased oxidation potential for carbidopa, with a linear dynamic range of 1.0 nM-120 M and a detection limit of 0.5 nM at pH = 7.0. The CPEM/Pt/SWCNTs sensor can detect carbidopa in water and dextrose saline with an acceptable recovery range.