Functionalized electrodes embedded in nanopores: read-out enhancement?

In this review, functionalized nanogaps embedded in nanopores are discussed in view of their high biosensitivity in detecting biomolecules, their length, type, and sequence. Specific focus is given on nanoelectrodes functionalized with tiny nanometer-sized diamond-like particles offering vast functionalization possibilities for gold junction electrodes. This choice of the functionalization, in turn, offers nucleotide-specific binding possibilities improving the detection signals arising from such functionalized electrodes potentially embedded in a nanopore. The review sheds light onto the use and enhancement of the tunnelling recognition in functionalized nanogaps towards sensing DNA nucleotides and mutation detection, providing important input for a practical realization.

Automated summary

This review discusses functionalized nanogaps embedded in nanopores, focusing on their high biosensitivity in detecting biomolecules and their length, type, and sequence. Specifically, the review highlights nanoelectrodes functionalized with tiny nanometer-sized diamond-like particles, which provide various functionalization possibilities for gold junction electrodes. This choice of functionalization offers nucleotide-specific binding possibilities, improving the detection signals from such functionalized electrodes potentially embedded in a nanopore.