4.6 Article

Quantum Yield of DNA Strand Breaks under Photoexcitation of a Molecular Ruby

Journal

CHEMISTRY-A EUROPEAN JOURNAL
Volume -, Issue -, Pages -

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202203719

Keywords

chromium; DNA origami; DNA strand breaks; photodynamic therapy; photosensitizer

Ask authors/readers for more resources

Photodynamic therapy (PDT) for cancer treatment relies on the generation of highly reactive oxygen species by light-induced excitation of a photosensitizer in the presence of molecular oxygen, causing DNA damage. Recently, the potential of photoactive complexes of non-noble metals as photosensitizers has been discovered.
Photodynamic therapy (PDT) used for treating cancer relies on the generation of highly reactive oxygen species, for example, singlet oxygen O-1(2), by light-induced excitation of a photosensitizer (PS) in the presence of molecular oxygen, inducing DNA damage in close proximity of the PS. Although many precious metal complexes have been explored as PS for PDT and received clinical approval, only recently, the potential of photoactive complexes of non-noble metals as PS has been discovered. Using the DNA origami technology that can absolutely quantify DNA strand break cross sections, we assessed the potential of the luminescent transition metal complex [Cr(ddpd)(2)](3+) (ddpd=N,N '-dimethyl-N,N '-dipyridine-2-ylpyridine-2,6-diamine) to damage DNA in an air-saturated aqueous environment upon UV/Vis illumination. The quantum yield for strand breakage, that is, the ratio of DNA strand breaks to the number of absorbed photons, was determined to 1-4 %, indicating efficient transformation of photons into DNA strand breaks by [Cr(ddpd)(2)](3+).

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available