Glycosyl Radical-Based Synthesis of C-Glycoamino Acids and C-Glycopeptides

Radical-based reactions usually exhibit excellent functional-group compatibilities due to their mild initiation conditions. Glycosyl radical involved C-glycosylation modifications are important strategies to achieve highly regio- and chemoselective constructions of C-glycosidic bonds or C-glycoside linkages of peptides and proteins. In this Concept, we cover recent developments in glycosyl radical-based synthesis of unnatural amino acids and late-stage modification of peptides and proteins, and provide a preliminary outlook on the possible development of this direction in the future.

Automated summary

This article summarizes the important application of radical-based reactions in glycosylation modifications, focusing on the synthesis of unnatural amino acids and the late-stage modification of peptides and proteins. It also provides an outlook on the future development in this direction.