Journal
CHEMISTRY & BIODIVERSITY
Volume 19, Issue 12, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.202200963
Keywords
deep-sea; Cladosporium oxysporum; fungus; secopatulolides; Vibrio parahemolyticus
Funding
- National Natural Science Foundation of China
- [22177143]
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Cladosporium fungi can produce various bioactive secondary metabolites, and ergosterol has a moderate inhibitory effect on Vibrio parahemolyticus.
The Cladosporium fungi, one of the largest genera of dematiaceous hyphomycetes, could produce various bioactive secondary metabolites. From the AcOEt-soluble extract of Cladosporium oxysporum 170103, three new secopatulolides (1-3) and thirteen known compounds (4-16) were obtained. Their structures were established by detailed analysis of the NMR and HR-ESI-MS data. All sixteen compounds were tested for antibacterial activity against Vibrio parahemolyticus, ergosterol (10) presented moderate effect with the minimum inhibitory concentration (MIC) of 32 mu M. It can destruct the membrane integrity of Vibrio parahemolyticus to change the cell shape.
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