Janus kinase/signal transducers and activator of transcription (JAK/STAT) and its role in Lung inflammatory disease

A key signaling channel for the signal transduction of several crucial cytokines implicated in sepsis is the JAK/ STAT system. Once cytokines attach to the proper receptors, JAK kinases linked to them are activated and can selectively phosphorylate STATs. Activated STATs subsequently go to the nucleus, where they play a key role in the transcription of the target genes. Various biological activities use the JAK/STAT pathway, including he-matopoiesis, immunological modulation, cell differentiation, and apoptosis. Inflammatory lung illnesses affect people worldwide and are a serious public health concern. Numerous common respiratory conditions, such as asthma, bronchiectasis, chronic obstructive pulmonary disease (COPD), and acute respiratory distress syndrome, are strongly influenced by inflammation. Microorganism infections or the destruction or demise of host cells are the causes of inflammation and the factors that perpetuate it. This review discusses the main elements of severe lung inflammation and how the JAK/STAT signaling pathway is essential for lung inflammation.

Automated summary

The JAK/STAT system is a crucial signaling pathway for the signal transduction of several key cytokines in sepsis. Activation of JAK kinases by cytokine-receptor binding leads to selective phosphorylation of STATs, which play a key role in gene transcription in the nucleus. The JAK/STAT pathway is involved in various biological activities, including hematopoiesis, immunological modulation, cell differentiation, and apoptosis. This review discusses the importance of the JAK/STAT signaling pathway in severe lung inflammation, which is a major public health concern worldwide.