Real-time visualization of the fluctuations in HOBr with AIE fluorescent probes during myocardial ischemia-reperfusion injury

Two fluorescent probes (QM-S and QM-Se) featuring AIE properties were developed. The increased intracellular hypobromous acid (HOBr) in cardiomyocytes during MIRI was revealed with these probes. It was also observed that MIRI might be alleviated by combating oxidative stress, as well as inhibiting inflammation and ferroptosis, which could mediate oxidative stress.

Automated summary

Two fluorescent probes (QM-S and QM-Se) with AIE properties were developed to reveal the increased intracellular hypobromous acid (HOBr) in cardiomyocytes during myocardial ischemia-reperfusion injury (MIRI). It was observed that MIRI could be alleviated by combating oxidative stress, as well as inhibiting inflammation and ferroptosis, which mediate oxidative stress.