Smart genetically-encoded biosensors for the chemical monitoring of living systems

Genetically-encoded biosensors provide the all-optical and non-invasive visualization of dynamic biochemical events within Living systems, which has allowed the discovery of profound new insights. Twenty-five years of biosensor development has steadily improved their performance and has provided us with an ever increasing biosensor repertoire. In this feature article, we present recent advances made in biosensor development and provide a perspective on the future direction of the field.

Automated summary

Genetically-encoded biosensors enable the visualization of dynamic biochemical events within living systems, providing new insights. Over the past 25 years, biosensor development has improved their performance and expanded the repertoire. This feature article presents recent advances and future directions in biosensor development.