Journal
CHEMICAL COMMUNICATIONS
Volume 59, Issue 8, Pages 1062-1065Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2cc06019a
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In this study, a new NHC-stabilized water-soluble Pd/Ni system is presented, which can perform H/D exchange reactions in an enantiospecific manner without reducing the aromatic ring of phenylalanine and tyrosine due to a synergetic Pd-Ni effect.
Labelling of amino-acids is important for the production of deuterated proteins. However, aromatic amino-acid reduction is a common undesired process with noble-metal nanocatalysts. In this work, we describe a new NHC-stabilized water-soluble Pd/Ni system able to perform H/D exchange reactions in an enantiospecific fashion without reducing the aromatic ring of phenylalanine and tyrosine thanks to a synergetic Pd-Ni effect.
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