Mitochondria-targeted fluorescent probe for imaging viscosity in hepatic ischemia-reperfusion injury cell model

The viscosity of the cell microenvironment is a parameter that affects cell physiological processes. A fluorescent probe X-V was designed to detect the viscosity changes of a hepatic ischemia-reperfusion injury (HIRI) cell model with high selectivity and sensitivity. The fluorescence emission wavelength is 615 nm and the Stokes shift can be up to 125 nm, which can be used not only for intracellular viscosity changes stimulated by different drugs but also for the detection of cell viscosity changes in the HIRI cell model. Probe X-V provides a useful tool to study the relationship between mitochondrial viscosity and related diseases.

Automated summary

The viscosity of cell microenvironment affects cell physiological processes. A fluorescent probe X-V was designed to detect viscosity changes in a hepatic ischemia-reperfusion injury (HIRI) cell model with high selectivity and sensitivity. The probe has a fluorescence emission wavelength of 615 nm and a Stokes shift of up to 125 nm, making it useful for studying intracellular viscosity changes and cell viscosity changes in the HIRI cell model. Probe X-V provides a valuable tool for studying the relationship between mitochondrial viscosity and related diseases.