Highly selective γ-alkoxylation, γ-amination and γ-alkylation of unbiased enals by means of photoredox catalysis

We report herein a general and highly selective gamma-functionalization protocol under visible light irradiation. This mild radical approach enables the expansion of the scope of application to unbiased enals and the introduction of a wide variety of alkoxy, amino and alkyl functionalities in the gamma position with complete regioselectivity.

Automated summary

We describe a versatile and highly selective method for gamma-functionalization under visible light. This gentle radical approach expands the application range to unbiased enals and allows the introduction of various alkoxy, amino, and alkyl functionalities at the gamma position with complete regioselectivity.