4.7 Article

Optochemical control of Cu(i) homeostasis in mammalian cells

Journal

CHEMICAL COMMUNICATIONS
Volume 59, Issue 16, Pages 2315-2318

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/d2cc05830h

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Copper can be both harmful and essential, and its concentration needs to be precisely controlled within cells. We have developed a system using a photocaged chelator and light to regulate cellular copper concentration. This method allows us to control copper levels in cells in a spatiotemporal manner.
Copper can act as a double-edged sword as it can cause fatal diseases when in excess or shortage. Precise control of copper homeostasis is maintained by a complex machinery inside cells. To overcome imbalances in copper concentration, we have developed a simple system to control the cellular copper concentration by using a photocaged chelator and light. This photocaged chelator allowed us to control cellular copper concentration in a spatiotemporal manner.

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