Organic photoredox catalyzed dealkylation/acylation of tertiary amines to access amides

A mild metal-free C-N bond activation strategy for the direct conversion of inert tertiary amines with acyl chlorides into tertiary amides via organic photoredox catalysis is presented. In this protocol, a novel organic photocatalyst (Cz-NI-Ph) that showed excellent catalytic performance during C-N bond cleavage is developed. Moreover, this reaction features green and mild conditions, broad substrate scope, and readily available raw materials.

Automated summary

A mild metal-free C-N bond activation strategy is introduced for the direct conversion of inert tertiary amines with acyl chlorides into tertiary amides via organic photoredox catalysis. A novel organic photocatalyst (Cz-NI-Ph) is developed, showing excellent catalytic performance in C-N bond cleavage. This reaction features green and mild conditions, broad substrate scope, and readily available raw materials.