Journal
CHEMICAL COMMUNICATIONS
Volume 59, Issue 1, Pages 51-54Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/d2cc05199k
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Funding
- EPSRC Centre for Doctoral Trainingin Synthesis for Biology and Medicine for a studentship [EP/L015838/1]
- AstraZeneca
- Diamond Light Source
- Defence Science and Technology Laboratory
- Evotec
- GlaxoSmithKline
- Janssen
- Novartis
- Pfizer
- Syngenta
- Takeda
- UCB
- Vertex
- Royal Society
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Photo-switchable receptors with spatial and temporal precision enable control over the binding and release of guests. In this study, the first halogen bonding photo-switchable anion receptors are reported, in which chloride binding can be reversibly modulated by irradiation with red and blue light. The Z isomer shows over a 50-fold enhancement in chloride binding affinity. This switchable binding enables unprecedented photo-controlled catalysis of XB-mediated halide abstractions and a Mukaiyama Aldol reaction.
Photo-switchable receptors allow for photo-control over guest binding and release with spatial and temporal precision. Here we report the first halogen bonding photo-switchable anion receptors in which chloride binding may be reversibly modulated by irradiation with red and blue light, with over a 50-fold enhancement in chloride binding affinity observed for the Z isomer. We demonstrate that this switchable binding enables unprecedented photo-controlled catalysis of XB-mediated halide abstractions and a Mukaiyama Aldol reaction.
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