Journal
CEREBRAL CORTEX
Volume 33, Issue 10, Pages 6282-6290Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhac503
Keywords
fMRI; functional connectivity; individual level; PD
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Individual-level cortical segmentation can provide additional individual information compared to group-level mapping studies in Parkinson's disease (PD). Functional connectivity analysis at the individual level is beneficial for clinical markers and treatment prediction. The study identified individualized functional connectivity between the visual network and sensorimotor network as a potential marker for estimating motor symptom severity in early-stage PD.
Abnormalities in functional connectivity networks are associated with sensorimotor networks in Parkinson's disease (PD) based on group-level mapping studies, but these results are controversial. Using individual-level cortical segmentation to construct individual brain atlases can supplement the individual information covered by group-level cortical segmentation. Functional connectivity analyses at the individual level are helpful for obtaining clinically useful markers and predicting treatment response. Based on the functional connectivity of individualized regions of interest, a support vector regression model was trained to estimate the severity of motor symptoms for each subject, and a correlation analysis between the estimated scores and clinical symptom scores was performed. Forty-six PD patients aged 50-75 years were included from the Parkinson's Progression Markers Initiative database, and 63 PD patients were included from the Beijing Rehabilitation Hospital database. Only patients below Hoehn and Yahr stage III were included. The analysis showed that the severity of motor symptoms could be estimated by the individualized functional connectivity between the visual network and sensorimotor network in early-stage disease. The results reveal individual-level connectivity biomarkers related to motor symptoms and emphasize the importance of individual differences in the prediction of the treatment response of PD.
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