Journal
JOURNAL OF NEUROVIROLOGY
Volume 22, Issue 6, Pages 871-875Publisher
SPRINGER
DOI: 10.1007/s13365-016-0449-0
Keywords
Progressive Multifocal Leukoencephalopathy (PML); JCV; Risk factors; Natalizumab; Tysabri
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Sixty-three natalizumab-treated patients with relapsing multiple sclerosis were screened for JC polyomavirus (JCV) viruria. Urinary-positive patients were longitudinally sampled for up to 24 weeks. Using methods that distinguish encapsidated virus from naked viral DNA, 17.5 % of patients were found to excrete virus, consistent with the prevalence of urinary excretion in the general population. Unexpectedly, urinary excretion was predominantly seen (> 73 %) in patients with high JC antibody index (>= 2.0). Active JCV infection, therefore, tends to occur in natalizumab patients that carry a high risk factor for the development of disease, directly linking JC infection to the risk factors for PML development.
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