Use of nanocellulose in the intracellular delivery of biological and non-biological drugs: a review

The need for natural, biodegradable, and biocompatible nanomaterials in drug delivery led to a great deal of interest in developing nanocellulose-based materials. This article emphasizes the potential of different types of nanocellulose in improving targeted intracellular drug delivery of biological and non-biological therapeutic molecules. Several new concepts and methods of employing nanocellulose to deliver therapeutic molecules, including less-studied biological agents, have been reviewed. Different types of nanocellulose, methods to extract or synthesize them, and various factors like size, shape, surface charge, hydrophilicity, etc. that affect intracellular drug delivery have also been discussed. Lastly, we discuss the current limitations associated with the extraction/synthesis of nanocellulose and its usage in targeted drug delivery, along with future prospects, including possible solutions to address the current challenges.

Automated summary

This article focuses on the potential of nanocellulose in enhancing targeted intracellular drug delivery. It discusses the delivery of different therapeutic molecules using nanocellulose and various methods of extracting or synthesizing nanocellulose. The factors affecting intracellular drug delivery, such as size, shape, surface charge, and hydrophilicity, are also explored. The article concludes by addressing the current limitations and future prospects of nanocellulose in drug delivery.