Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 79, Issue 12, Pages -Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-022-04589-4
Keywords
Trophoblast; Placenta; Embryo; Gene expression; Stem cells; Blastoids
Categories
Funding
- Tier II Canada Research Chair in maternal-fetal medicine
- Undergraduate Research Opportunity Fund from the Department of Physiology at the University of Toronto
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Trophoblast plays a critical role in reproduction, cancer, and transplantation. Researchers integrate different datasets to validate the utility and applicability of hTSC models, and also study the process of human embryonic development.
A recent explosion of methods to produce human trophoblast and stem cells (hTSCs) is fuelling a renewed interest in this tissue. The trophoblast is critical to reproduction by facilitating implantation, maternal physiological adaptations to pregnancy and the growth of the fetus through transport of nutrients between the mother and fetus. More broadly, the trophoblast has phenotypic properties that make it of interest to other fields. Its angiogenic and invasive properties are similar to tumours and could identify novel drug targets, and its ability to regulate immunological tolerance of the allogenic fetus could lead to improvements in transplantations. Within this review, we integrate and assess transcriptomic data of cell-based models of hTSC alongside in vivo samples to identify the utility and applicability of these models. We also integrate single-cell RNA sequencing data sets of human blastoids, stem cells and embryos to identify how these models may recapitulate early trophoblast development.
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