Journal
CELLULAR AND MOLECULAR BIOENGINEERING
Volume 16, Issue 1, Pages 23-39Publisher
SPRINGER
DOI: 10.1007/s12195-022-00750-y
Keywords
Triple-negative breast cancer; Hypertrophy; Microphysiological system; Tumor engineering; Fat; Microvascular tissue engineering; Intravasation
Ask authors/readers for more resources
This study demonstrates that the presence of adipose cells, regardless of the obesity status of the adipose tissue donor, hastens the escape of human breast cancer cells in multiple models of obesity-associated breast cancer.
Introduction & mdash;Obesity is associated with increased breast cancer incidence, recurrence, and mortality. Adipocytes and adipose-derived stem cells (ASCs), two resident cell types in adipose tissue, accelerate the early stages of breast cancer progression. It remains unclear whether obesity plays a role in the subsequent escape of malignant breast cancer cells into the local circulation.Methods & mdash;We engineered models of human breast tumors with adipose stroma that exhibited different obesity-specific alterations. We used these models to assess the invasion and escape of breast cancer cells into an empty, blind-ended cavity (as a mimic of a lymphatic vessel) for up to sixteen days.Results & mdash;Lean and obese donor-derived adipose stroma hastened escape to similar extents. Moreover, a hypertrophic adipose stroma did not affect the rate of adipose-induced escape. When admixed directly into the model tumors, lean and obese donor-derived ASCs hastened escape similarly.Conclusions & mdash;This study demonstrates that the presence of adipose cells, independently of the obesity status of the adipose tissue donor, hastens the escape of human breast cancer cells in multiple models of obesity-associated breast cancer.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available