Journal
CELL METABOLISM
Volume 35, Issue 1, Pages 118-+Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2022.12.003
Keywords
-
Categories
Ask authors/readers for more resources
T cell-mediated immunosurveillance in early-stage tumorigenesis guides metabolic reprogramming in tumor cells through non-canonical interferon gamma (IFNg)-STAT3 signaling, leading to immune evasion and the formation of a suppressive tumor microenvironment.
Immunoediting sculpts immunogenicity and thwarts host anti-tumor responses in tumor cells during tumor-igenesis; however, it remains unknown whether metabolic programming of tumor cells can be guided by immunosurveillance. Here, we report that T cell-mediated immunosurveillance in early-stage tumorigenesis instructs c-Myc upregulation and metabolic reprogramming in tumor cells. This previously unexplored tu-mor-immune interaction is controlled by non-canonical interferon gamma (IFNg)-STAT3 signaling and sup-ports tumor immune evasion. Our findings uncover that immunoediting instructs deregulated bioenergetic programs in tumor cells to empower them to disarm the T cell-mediated immunosurveillance by imposing metabolic tug-of-war between tumor and infiltrating T cells and forming the suppressive tumor microenvi-ronment.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available