Holding it together: Nanoparticle stabilization of LASV trimer

The development of Lassa virus (LASV) vaccines has been challenging due to the instability of recombinant immunogens. In this issue of Cell Host & Microbe, Brouwer et al. use a two-component nanoparticle strategy that enables stable trimeric presentation of the LASV glycoprotein complex (GPC) and induction of broadly neutralizing antibodies.

Automated summary

This study successfully stabilized the presentation of LASV immunogens and induced the production of broadly neutralizing antibodies using a novel nanoparticle strategy.