Need for speed: Key driver of host cell migration varies among mycobacteria

In this issue of Cell, Saelens et al. describe a new function for mycobacterial Type VII secretion systems: manipulation of host cell migration. They find that a substantial proportion of global TB cases arise from bacteria lacking this function, raising questions about its role in pathoadaptation of Mycobacterium tuberculosis.

Automated summary

In this study, Saelens et al. uncover a novel function of mycobacterial Type VII secretion systems in manipulating host cell migration. The absence of this function in a substantial proportion of global TB cases raises questions about its role in pathoadaptation of Mycobacterium tuberculosis, providing new insights for further investigations.