Development of magnetic Fe3O4-chitosan immobilized Cu(II) Schiff base catalyst: An efficient and reusable catalyst for microwave assisted one-pot synthesis of propargylamines via A3 coupling

A novel heterogeneous catalyst (Fe3O4@CS@Schiffbase@Cu) is developed by generating the Cu(II) Schiff base complex on the Fe3O4-chitosan surface. The structural and morphological characteristics of the catalyst is confirmed by all physicochemical techniques. A low catalyst loading (1.1 mol% Cu) of the immobilized Cu(II) Schiff base complex shows its catalytic activity for A3 coupling reaction of Aldehyde, Alkyne, and Amines under microwave irradiation. The catalyst was proven very active for a wide variety of propargylamines syntheses using different substituted aromatic aldehydes, secondary amines, and phenylacetylene under optimized con-ditions. The recyclability of the catalyst was efficient even after six cycles with a 95% efficiency.

Automated summary

A novel heterogeneous catalyst (Fe3O4@CS@Schiffbase@Cu) was developed by generating the Cu(II) Schiff base complex on the Fe3O4-chitosan surface. The catalyst's structural and morphological characteristics were confirmed using physicochemical techniques. The immobilized Cu(II) Schiff base complex with low catalyst loading (1.1 mol% Cu) showed catalytic activity for the A3 coupling reaction of Aldehyde, Alkyne, and Amines under microwave irradiation. The catalyst was highly active for the synthesis of various propargylamines and showed efficient recyclability with a 95% efficiency even after six cycles.