Acid sphingomyelinase promotes diabetic cardiomyopathy via NADPH oxidase 4 mediated apoptosis

Article Substance Abuse

Ectopic accumulation of ceramide in cardiomyocytes modulates alcoholic cardiomyopathy via the TLR4-dependent pathway

Cui Wang et al.

Summary: Our study reveals that the accumulation of ceramide plays a critical role in alcoholic cardiomyopathy, which is partially mediated through the TLR4-dependent pathway.

ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH (2022)

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Article Cardiac & Cardiovascular Systems

Circulating ceramides and sphingomyelins and the risk of incident cardiovascular disease among people with diabetes: the strong heart study

Paul N. Jensen et al.

Summary: This study found associations between certain ceramide and sphingomyelin species in plasma and the risk of diabetes and cardiovascular diseases (CVD). Specifically, Cer-16 was associated with higher risk of diabetes and CVD, while sphingomyelin species with long chain saturated fatty acid were associated with lower CVD risk among individuals with type 2 diabetes.

CARDIOVASCULAR DIABETOLOGY (2022)

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Article Cardiac & Cardiovascular Systems

The Acid Sphingomyelinase Inhibitor Amitriptyline Ameliorates TNF-α-Induced Endothelial Dysfunction

Yang Ji et al.

Summary: The study showed that amitriptyline can enhance eNOS phosphorylation and release of NO, inhibit ASMase activity and ceramide release induced by TNF-alpha, downregulate expression of proinflammatory proteins, and improve endothelial function.

CARDIOVASCULAR DRUGS AND THERAPY (2022)

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Article Medicine, Research & Experimental

Targeting the ASMase/S1P pathway protects from sortilin-evoked vascular damage in hypertension

Paola Di Pietro et al.

Summary: Sortilin plays a crucial role in vascular dysfunction and blood pressure homeostasis, and has the potential to be used as a biomarker for predicting vascular dysfunction and high blood pressure.

JOURNAL OF CLINICAL INVESTIGATION (2022)

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Article Biochemistry & Molecular Biology

The role of ceramide accumulation in human induced pluripotent stem cell-derived cardiomyocytes on mitochondrial oxidative stress and mitophagy

Mohamed Bekhite et al.

Summary: Ceramide accumulation in cardiomyocytes contributes to insulin resistance, oxidative stress, increased auto/mitophagy, and mitochondrial dysfunction in the setting of lipotoxic cardiomyopathy, highlighting the importance of targeting the de novo ceramide synthesis pathway as a potential therapeutic strategy.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

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Article Cardiac & Cardiovascular Systems

Nampt Potentiates Antioxidant Defense in Diabetic Cardiomyopathy

Shin-Ichi Oka et al.

Summary: This study investigated the role of Nampt in the development of diabetic cardiomyopathy induced by high-fat diet consumption. The findings suggest that overexpression of Nampt can alleviate cardiac diabetic pathology and oxidative stress, protecting cardiac function.

CIRCULATION RESEARCH (2021)

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Editorial Material Medicine, Research & Experimental

Fuse your mitochondria, lose appetite: an anorexic, anti-obesity sphingolipid

Carolin Muley et al.

Summary: Aberrant production of ceramides, the precursors of complex sphingolipids, is associated with obesity and metabolic dysfunction. The length of ceramide side chains determines their lipotoxicity, and inhibiting synthesis or promoting degradation of ceramides can help mitigate the harmful effects of high-fat diets. However, drugs targeting ceramide metabolism have not shown metabolic benefits in human trials so far.

EMBO MOLECULAR MEDICINE (2021)

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Review Medicine, General & Internal