4.7 Article

Dopamine-modified chitosan hydrogel for spinal cord injury

Journal

CARBOHYDRATE POLYMERS
Volume 298, Issue -, Pages -

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2022.120047

Keywords

Chitosan hydrogel; Citric acid; Dopamine; Spinal cord injury

Funding

  1. National Key Research and Development Program of China [2018YFB1105500]
  2. National Natural Science Foundation of China [51772233]
  3. Major Special Project of Technological Innovation of Hubei Province [2019ACA130]
  4. Key Basic Research Program of Shenzhen [JCYJ20200109150218836]
  5. Application Foundation and Front Research Program of Wuhan [2018010401011273]
  6. Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory [XHT2020-008]

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A dopamine-modified chitosan hydrogel was designed to improve the microenvironment of spinal cord injury. In vitro and in vivo experiments demonstrated that the dopamine-modified hydrogel enhanced cell survival, modulated immune response, and promoted axonal regeneration in injured spinal cord.
Spinal cord injury (SCI) decreases people's both physical and psychological levels. The rehabilitation of SCI is still a clinical challenging process owing to the inflammatory environment for cell survival. Herein, we designed a dopamine-modified chitosan hydrogel to improve poor microenvironment of spinal cord injury. Dopamine modified chitosan hydrogel was fabricated by crosslinking with citric acid (CS-CA-DA), which address the insufficient mechanical properties. In vitro analysis showed that dopamine modification improved the cell sur-vival and cell adhesion. Moreover, implantation of CS-CA-DA hydrogel alone into rat injured spinal cord helped improving cell survivals, modulating immunity, promoting macrophage polarization to the M2 phenotype and promoting axonal regeneration in vivo in brutal areas of SCI. This strategy of modified chitosan with dopamine undergoing a high mechanical properties, excellent cell compatibility and antioxidant performance, providing a new insight into repairing spinal cord injury.

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