Journal
CARBOHYDRATE POLYMERS
Volume 298, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2022.120130
Keywords
AIE; Cyclodextrin; Cell imaging; Drug delivery system
Categories
Funding
- National Natural Science Foundation of China
- [51263009]
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Amphiphilic AIE nanoparticles CD-TPE with good water dispersibility and the ability to load and release doxorubicin were synthesized through a one-step reaction. CD-TPE exhibited promising applications in drug delivery, showing good biocompatibility and excellent cell imaging performance. In vitro and in vivo experiments demonstrated the potential value of CD-TPE in the field of drug delivery.
Amphiphilic AIE nanoparticles (CD-TPE) were obtained by linking gamma-cyclodextrin (gamma-CD) and 1, 2-diphenyl-1, 2-(p-hydroxyphenyl)-ethylene (OH-TPE-OH) by an esterification reaction using hexamethylene diisocyanate (HMDI) in a one-step process. The CD-TPE was characterized by FTIR, 13C NMR, DSC, XRD, particle size analysis, TEM, and FL. The obtained CD-TPE had good water dispersibility and could self-assemble into AIE nanoparticles. The large cavity of CD-TPE provided convenient conditions for the loading of doxorubicin (DOX) and slow -release DOX with the loading and release rates of 67.4 % and 71.3 % (pH = 5.4), respectively. The DOX release kinetic model was suitable for the Bhaskar model. Cytotoxicity analysis and cell imaging of CD-TPE were performed, showing that CD-TPE has good biocompatibility and excellent cell imaging performance. Moreover, both in vitro and in vivo antitumor experiments showed that CD-TPE has promising applications in drug delivery.
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