Journal
CARBOHYDRATE POLYMERS
Volume 298, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2022.120072
Keywords
Polysaccharides; Fucosylated glycosaminoglycan; Oligosaccharides; Sea cucumber; Anticoagulant activity
Categories
Funding
- Natural Science Foundation of Guangxi Zhuang Autonomous Region [2020GXNSFFA297005]
- Specific Research Project of Guangxi for Research Bases and Talents [AD21159002]
- National Natural Science Foundation of China [32160220, 82160738]
- Development Program of High-level Talent Team under the Qihuang Project of Guangxi University of Chinese Medicine [2021004]
- Special Fund for Bagui Scholars of Guangxi [05019055]
- Scientific Research Foundation of GXUCM [2019BS022, 2019BS023, 2019XK106]
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The tropical sea cucumber Stichopus monotuberculatus exhibits strong anticoagulant activity by selectively inhibiting intrinsic tenase complex. The anticoagulant activity decreases with the decrease of molecular weight, while the unusual branch and novel reducing end may enhance anticoagulant activity.
Stichopus monotuberculatus is a tropical sea cucumber species and used as a folk medicine and tonic food. In this study, a fucosylated glycosaminoglycan (SmFG), the depolymerized SmFG (dSmFG) and its oligosaccharide fractions were prepared. The SmFG and its depolymerized products were comprised of a chondroitin-sulfate-E backbone, and various sulfated fucose side chains, including an unusual disaccharide side chain connected to the C-3 position of D-glucuronic acid (GlcA) or GlcA-ol. A peeling reaction occurred during the deaminative depolymerization process. The dSmFG and its fractions showed strong anticoagulant activity by selectively inhibiting intrinsic tenase complex, and had no anti-factor IIa, Xa and VIIa activity. The anticoagulant activity reduced with the decrease of molecular weight, and the unusual branch and novel reducing end may enhance the anticoagulant activity. These findings can provide significant information for development and utilization of depolymerized products from SmFG in food and pharmaceutical industries.
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