4.5 Article

Rac1 promotes the reprogramming of glucose metabolism and the growth of colon cancer cells through upregulating SOX9

Related references

Note: Only part of the references are listed.
Article Cell Biology

Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of I?Ba

Dong Guo et al.

Summary: High glucose promotes PD-L1 expression in tumor cells, leading to tumor immune evasion. Inhibition of HK2 and PD-1 can eliminate tumor immune evasion and enhance the anti-tumor effect of immune checkpoint blockade.

CELL METABOLISM (2022)

Article Cell Biology

The PKGIα-Rac1 pathway is a novel regulator of insulin-dependent glucose uptake in cultured rat podocytes

Irena Audzeyenka et al.

Summary: The study demonstrates that the PKGI alpha-dependent Rac1 signaling pathway enhances insulin-mediated glucose uptake in podocytes, while downregulation of PKGI alpha or Rac1 expression abolishes this effect. Silencing of Rac1 prevents actin remodeling and GLUT4 translocation to the cell membrane.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

Article Multidisciplinary Sciences

Hexokinase 2-driven glycolysis in pericytes activates their contractility leading to tumor blood vessel abnormalities

Ya-Ming Meng et al.

Summary: The interaction between pericytes and endothelial cells in tumor vasculature plays a crucial role in tumorigenesis and therapy efficacy. High levels of glycolysis driven by hexokinase 2 in tumor pericytes activate contractility, leading to impaired blood vessel supporting function. Inhibition of HK2 in pericytes results in tumor vasculature remodeling and enhanced drug delivery against tumor growth.

NATURE COMMUNICATIONS (2021)

Article Immunology

TGF-β Signaling Promotes Glioma Progression Through Stabilizing Sox9

Min Chao et al.

Summary: Sox9, an upregulated transcription factor in clinical gliomas associated with poor prognosis, promotes migration and invasion of glioma cells and in vivo tumor development. It functions downstream of the TGF-beta pathway, where TGF-beta signaling prevents proteasomal degradation of Sox9 protein in glioma cells. These findings provide new insights into the interaction between TGF-beta signaling and oncogenic transcription factors, with implications for targeted therapy and prognostic assessment of gliomas.

FRONTIERS IN IMMUNOLOGY (2021)

Review Oncology

The role of SOX family members in solid tumours and metastasis

Daniela Grimm et al.

SEMINARS IN CANCER BIOLOGY (2020)

Article Endocrinology & Metabolism

An AMPK/Axin1-Rac1 signaling pathway mediates contraction-regulated glucose uptake in skeletal muscle cells

Yingying Yue et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2020)

Article Medicine, Research & Experimental

Metabolic classification of circulating tumor cells as a biomarker for metastasis and prognosis in breast cancer

Jing Chen et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

Review Pharmacology & Pharmacy

SOX9: The master regulator of cell fate in breast cancer

Samir Jana et al.

BIOCHEMICAL PHARMACOLOGY (2020)

Review Multidisciplinary Sciences

Metabolic reprogramming and cancer progression

Brandon Faubert et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

Rac1 activates non-oxidative pentose phosphate pathway to induce chemoresistance of breast cancer

Qingjian Li et al.

NATURE COMMUNICATIONS (2020)

Article Oncology

Rac1 repression reverses chemoresistance by targeting tumor metabolism

Shanmugasundaram Ganapathy-Kanniappan

CANCER BIOLOGY & THERAPY (2020)

Review Biology

The Warburg effect: essential part of metabolic reprogramming and central contributor to cancer progression

Peter Vaupel et al.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2019)

Article Biotechnology & Applied Microbiology

Diallyl disulfide inhibits colon cancer metastasis by suppressing Rac1-mediated epithelial-mesenchymal transition

Longzheng Xia et al.

ONCOTARGETS AND THERAPY (2019)

Review Gastroenterology & Hepatology

Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies

NaNa Keum et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

Review Oncology

Biological Role and Therapeutic Potential of IDH Mutations in Cancer

Matthew S. Waitkus et al.

CANCER CELL (2018)

Article Oncology

NCCN Guidelines® Insights Colon Cancer, Version 2.2018 Featured Updates to the NCCN Guidelines

Al B. Benson et al.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2018)

Review Endocrinology & Metabolism

Macropinocytosis: A Metabolic Adaptation to nutrient Stress in Cancer

Maria Victoria Recouvreux et al.

FRONTIERS IN ENDOCRINOLOGY (2017)

Article Biochemistry & Molecular Biology

FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma

Aldwin Suryo Rahmanto et al.

EMBO JOURNAL (2016)

Review Oncology

Personalizing Colon Cancer Adjuvant Therapy: Selecting Optimal Treatments for Individual Patients

Rodrigo Dienstmann et al.

JOURNAL OF CLINICAL ONCOLOGY (2015)

Article Oncology

Challenges to effective cancer control in China, India, and Russia

Paul E. Goss et al.

LANCET ONCOLOGY (2014)

Article Oncology

Acidity Generated by the Tumor Microenvironment Drives Local Invasion

Veronica Estrella et al.

CANCER RESEARCH (2013)

Review Biotechnology & Applied Microbiology

Therapeutic targets in cancer cell metabolism and autophagy

Heesun Cheong et al.

NATURE BIOTECHNOLOGY (2012)

Article Biochemistry & Molecular Biology

Thrombin Induces NF-κB Activation and IL-8/CXCL8 Expression in Lung Epithelial Cells by a Rac1-dependent PI3K/Akt Pathway

Chien-Huang Lin et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Metabolic Alterations in Highly Tumorigenic Glioblastoma Cells PREFERENCE FOR HYPOXIA AND HIGH DEPENDENCY ON GLYCOLYSIS

Yunfei Zhou et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Gastroenterology & Hepatology

SOX9 is expressed in normal stomach, intestinal metaplasia, and gastric carcinoma in humans

Miho Sashikawa Kimura et al.

JOURNAL OF GASTROENTEROLOGY (2011)

Review Biochemistry & Molecular Biology

Rac1 GTPase: A Rac of All Trades

E. E. Bosco et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2009)

Article Biotechnology & Applied Microbiology

Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy

Joshua Munger et al.

NATURE BIOTECHNOLOGY (2008)

Review Oncology

Multifaceted role of Rho proteins in angiogenesis

Sofia D. Merajver et al.

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA (2005)

Review Biochemistry & Molecular Biology

Rho GTPases in human cancer:: an unresolved link to upstream and downstream transcriptional regulation

SA Benitah et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2004)

Article Medicine, General & Internal

Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer

T Andre et al.

NEW ENGLAND JOURNAL OF MEDICINE (2004)