Prognostic significance of natural products against multidrug tumor resistance

Cancer is a pervasive, constantly evolving, and significant public health concern. The number of new cancer cases has risen dramatically in the last decades, making it one of the top causes of poor health and mortality worldwide. Although various treatment strategies, including surgery, radiation, and pharmaceutical therapies, have evolved into more sophisticated, precise methods, there is not much improvement in the cancer-related death toll. Consequently, natural product-based therapeutic discoveries have recently been considered an alternative approach. According to an estimate, one-third of the top twenty medications in today's market have a natural plant-product-based origin. Accordingly, primary prevention is an essential component of worldwide cancer control. This review provides an overview of the mechanisms of action of bioactive ingredients in natural dietary products that may contribute to the prevention and management of multiple malignancies.

Automated summary

Cancer is a widespread and constantly evolving disease that poses a significant public health concern. Despite advancements in treatment strategies, such as surgery, radiation, and pharmaceutical therapies, there has been little improvement in cancer-related death rates. As a result, natural product-based therapeutic discoveries are being considered as an alternative approach. Primary prevention plays a crucial role in global cancer control, and this review provides an overview of the mechanisms by which bioactive ingredients in natural dietary products may contribute to the prevention and management of various malignancies.