4.7 Article

Anti-4-1BB immunotherapy enhances systemic immune effects of radiotherapy to induce B and T cell-dependent anti-tumor immune activation and improve tumor control at unirradiated sites

Related references

Note: Only part of the references are listed.
Article Medicine, General & Internal

Relatlimab and Nivolumab versus Nivolumab in Untreated Advanced Melanoma

Hussein A. Tawbi et al.

Summary: LAG-3 and PD-1 are two distinct inhibitory immune checkpoints that contribute to T-cell exhaustion. The combination of relatlimab and nivolumab has been shown to be safe and effective in previously treated melanoma patients, and this study aimed to evaluate its safety and activity in previously untreated melanoma patients. The results demonstrated that the combination therapy provided a greater benefit in terms of progression-free survival compared to nivolumab alone, without any new safety signals.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

Article Oncology

Activated B Cells and Plasma Cells Are Resistant to Radiation Therapy

Ida Franiak-Pietryga et al.

Summary: This study characterizes the effects of radiation on the development, survival, and phenotype of B-cell subsets. It demonstrates that focal stereotactic radiation is superior to large-field radiation in inducing immune cell infiltration into tumors and that plasma cells and class switched B cells are highly resistant to radiation therapy.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2022)

Article Oncology

Low-Dose Radiotherapy Reverses Tumor Immune Desertification and Resistance to Immunotherapy

Fernanda G. Herrera et al.

Summary: Developing strategies to inflame tumors is critical for increasing response to immunotherapy. Low-dose radiation reprograms the tumor microenvironment to promote T-cell infiltration and, when combined with immunotherapy, simultaneously mobilizes innate and adaptive immunity, predominantly CD4(+) effector T cells, for tumor control dependent on NKG2D. This combination induces important responses in patients with metastatic immune-cold tumors.

CANCER DISCOVERY (2022)

Article Oncology

Prospective Single-Arm Phase 1 and 2 Study: Ipilimumab and Nivolumab With Thoracic Radiation Therapy After Platinum Chemotherapy in Extensive-Stage Small Cell Lung Cancer

Bradford A. Perez et al.

Summary: The study investigated the addition of ipilimumab and nivolumab after thoracic radiation therapy for patients with extensive stage small cell lung cancer, showing higher than expected overall survival rates. Increased CD3+CD8+ tumor infiltration was associated with favorable outcomes in terms of progression-free survival and overall survival.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2021)

Article Oncology

Randomized Phase II Trial of Nivolumab With Stereotactic Body Radiotherapy Versus Nivolumab Alone in Metastatic Head and Neck Squamous Cell Carcinoma

Sean McBride et al.

Summary: The study compared the efficacy of nivolumab alone versus nivolumab plus SBRT in treating patients with metastatic HNSCC, and found that the addition of SBRT did not improve treatment response in unselected patients.

JOURNAL OF CLINICAL ONCOLOGY (2021)

Article Biochemistry & Molecular Biology

Ablative Radiotherapy Reprograms the Tumor Microenvironment of a Pancreatic Tumor in Favoring the Immune Checkpoint Blockade Therapy

Yu-Hung Lee et al.

Summary: The study found that ablative RT is more effective at recruiting T cells compared to fractionated RT, while fractionated RT leads to more myeloid-derived suppressor cell infiltration. The RT-disturbed TME has a higher perfusion rate, allowing more anti-PD-L1 antibody to reach the tumor.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Multidisciplinary Sciences

IgA transcytosis and antigen recognition govern ovarian cancer immunity

Subir Biswas et al.

Summary: Most ovarian cancers are infiltrated by activated T cells that have prognostic relevance, but they show low response rates to immune checkpoint inhibitors. On the contrary, memory B cell and plasma cell infiltrates associated with better outcomes may exert protective effects against tumor cells through B cell-derived IgA in ovarian cancer.

NATURE (2021)

Review Cell Biology

Biomarkers of Radiotherapy-Induced Immunogenic Cell Death

Rianne D. W. Vaes et al.

Summary: Radiation therapy can induce immunogenic cell death and release various immunogenic factors, but the search for biomarkers predicting immunogenic cell death in tumor cells remains limited. This review summarizes the available literature on potential biomarkers of radiation-induced immunogenic cell death evaluated in cancer patients and discusses their clinical relevance.

CELLS (2021)

Article Multidisciplinary Sciences

Functional HPV-specific PD-1+ stem-like CD8 T cells in head and neck cancer

Christiane S. Eberhardt et al.

Summary: The study identified different transcriptional subsets of HPV-specific CD8 T cells in HPV-positive head and neck cancer, highlighting the potential response to PD-1 blockade. Furthermore, the inclusion of E2 and E5 proteins in HPV therapeutic vaccines should be considered to elicit a broader tumor-reactive CD8 T cell response.

NATURE (2021)

Review Biotechnology & Applied Microbiology

Role of Inducible Co-Stimulator (ICOS) in cancer immunotherapy

Florent Amatore et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2020)

Article Multidisciplinary Sciences

Tertiary lymphoid structures improve immunotherapy and survival in melanoma

Rita Cabrita et al.

NATURE (2020)

Article Multidisciplinary Sciences

B cells and tertiary lymphoid structures promote immunotherapy response

Beth A. Helmink et al.

NATURE (2020)

Editorial Material Oncology

The Promise of Combining Radiation Therapy With Immunotherapy

Justin C. Jagodinsky et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2020)

Article Oncology

Radiotherapy Cooperates with IL15 to Induce Antitumor Immune Responses

Karsten A. Pilones et al.

CANCER IMMUNOLOGY RESEARCH (2020)

Review Oncology

T-cell agonists in cancer immunotherapy

Yeonjoo Choi et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

Article Medicine, Research & Experimental

Differentiated agonistic antibody targeting CD137 eradicates large tumors without hepatotoxicity

Ugur Eskiocak et al.

JCI INSIGHT (2020)

Article Multidisciplinary Sciences

Tumor-reprogrammed resident T cells resist radiation to control tumors

Ainhoa Arina et al.

NATURE COMMUNICATIONS (2019)

Article Oncology

Clinical Development of PD-1 in Advanced Melanoma

Rodrigo Ramella Munhoz et al.

CANCER JOURNAL (2018)

Article Oncology

Dose-limiting Urinary Toxicity With Pembrolizumab Combined With Weekly Hypofractionated Radiation Therapy in Bladder Cancer

Alison Claire Tree et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2018)

Article Oncology

Exosomes Shuttle TREX1-Sensitive IFN-Stimulatory dsDNA from Irradiated Cancer Cells to DCs

Julie M. Diamond et al.

CANCER IMMUNOLOGY RESEARCH (2018)

Review Oncology

Using immunotherapy to boost the abscopal effect

Wilfred Ngwa et al.

NATURE REVIEWS CANCER (2018)

Article Multidisciplinary Sciences

Host STING-dependent MDSC mobilization drives extrinsic radiation resistance

Hua Liang et al.

NATURE COMMUNICATIONS (2017)

Article Multidisciplinary Sciences

DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity

Claire Vanpouille-Box et al.

NATURE COMMUNICATIONS (2017)

Review Oncology

4-1BB (CD137) and radiation therapy: A case report and literature review

Jay C. Shiao et al.

ADVANCES IN RADIATION ONCOLOGY (2017)

Review Oncology

Systematic review of case reports on the abscopal effect

Yazan Abuodeh et al.

CURRENT PROBLEMS IN CANCER (2016)

Review Oncology

Rationale for anti-OX40 cancer immunotherapy

Sandrine Aspeslagh et al.

EUROPEAN JOURNAL OF CANCER (2016)

Article Multidisciplinary Sciences

Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

Christina Twyman-Saint Victor et al.

NATURE (2015)

Article Medicine, General & Internal

Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung Cancer

Julie Brahmer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Medicine, General & Internal

Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer

H. Borghaei et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Immunology

CD137 Promotes Proliferation and Survival of Human B Cells

Xiaoyu Zhang et al.

JOURNAL OF IMMUNOLOGY (2010)

Article Medicine, General & Internal

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

F. Stephen Hodi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Article Immunology

Requirement of B Cells for Generating CD4+ T Cell Memory

Jason K. Whitmire et al.

JOURNAL OF IMMUNOLOGY (2009)

Article Immunology

Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells

Satoko Matsumura et al.

JOURNAL OF IMMUNOLOGY (2008)

Article Immunology

Expression and function of 4-1BB and 4-1BB ligand on murine dendritic cells

T Futagawa et al.

INTERNATIONAL IMMUNOLOGY (2002)

Article Immunology

Tumours can act as adjuvants for humoral immunity

DM Brown et al.

IMMUNOLOGY (2001)