The Relationship between Diabetes Mellitus and Pancreatic Cancer-Diabetes Mellitus as a Red Flag for Pancreatic Cancer

The relationship between diabetes mellitus (DM) and pancreatic cancer is complex-DM is both a risk factor and early sign of pancreatic cancer. DM is a risk factor for pancreatic cancer because it increases insulin resistance, intrapancreatic concentrations of insulin, and the bioavailability of IGF, subsequently promoting ductal cell proliferation. Accordingly, treatment targeting the insulin/IGF pathway is the focus of many researchers. Antidiabetic drugs modify the risk for pancreatic cancer-metformin's antineoplastic effect being most notable and indicating potential clinical use in pancreatic cancer. New-onset DM can also be the first manifestation of pancreatic cancer. There are several theories for the

Automated summary

The relationship between diabetes mellitus (DM) and pancreatic cancer is complex, as DM can be both a risk factor and an early sign of pancreatic cancer. DM increases the risk of pancreatic cancer by promoting ductal cell proliferation through increased insulin resistance and intrapancreatic concentrations of insulin and IGF. Targeting the insulin/IGF pathway in treatment is a focus of research, and antidiabetic drugs like metformin have shown potential for clinical use in pancreatic cancer. Additionally, new-onset DM can be an early indication of pancreatic cancer.