Journal
CANCER CELL
Volume 40, Issue 12, Pages 1600-+Publisher
CELL PRESS
DOI: 10.1016/j.ccell.2022.11.002
Keywords
-
Categories
Funding
- Flemish government FWO [G0A0818N]
- National Institutes of Health, National Cancer Institute (NIH/NCI) [R01CA201537]
- Kom op tegen Kanker, Emmanuel van der Schueren starter fellowship [2018/11321/2822]
- Academy of Finland
- Finnish Cancer Foundation
- Jane and Aatos Erkko Foundation
- Sigrid Juselius Foundation
Ask authors/readers for more resources
The lack of T cell infiltrates hinders effective immunotherapy in cancer, while the formation of tumor-associated tertiary-lymphoid-like structures (TA-TLLSs) is associated with a good prognosis. This study reveals that antiangiogenic immune-modulating therapies can induce the transformation of postcapillary venules into inflamed high-endothelial venules (HEVs) through lymphotoxin/lymphotoxin beta receptor (LT/LTbR) signaling. Tumor HEVs enhance intratumoral lymphocyte influx and promote the differentiation of CD8 T cell progenitors into effector cells, contributing to tumor immunotherapy.
The lack of T cell infiltrates is a major obstacle to effective immunotherapy in cancer. Conversely, the forma-tion of tumor-associated tertiary-lymphoid-like structures (TA-TLLSs), which are the local site of humoral and cellular immune responses against cancers, is associated with good prognosis, and they have recently been detected in immune checkpoint blockade (ICB)-responding patients. However, how these lymphoid aggre-gates develop remains poorly understood. By employing single-cell transcriptomics, endothelial fate map-ping, and functional multiplex immune profiling, we demonstrate that antiangiogenic immune-modulating therapies evoke transdifferentiation of postcapillary venules into inflamed high-endothelial venules (HEVs) via lymphotoxin/lymphotoxin beta receptor (LT/LTbR) signaling. In turn, tumor HEVs boost intratumoral lymphocyte influx and foster permissive lymphocyte niches for PD1(-) and PD1(+)TCF1(+) CD8 T cell progenitors that differentiate into GrzB(+)PD1(+) CD8 T effector cells. Tumor-HEVs require continuous CD8 and NK cell -derived signals revealing that tumor HEV maintenance is actively sculpted by the adaptive immune system through a feed-forward loop.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available