COMPLEXATION OF ALKALINE EARTH METALS Mg2+, Ca2+, Sr2+ AND Ba2+ WITH ADRENALINE HORMONE: SYNTHESIS, SPECTROSCOPIC AND ANTIMICROBIAL ANALYSIS

Adrenaline complexes with bivalent ions Mg2+, Ca2+, Sr2+ and Ba2+ in methanol at 60 degrees C were prepared. The prepared complexes were isolated and characterized using elemental analyses, conductivity measurements, mid infrared, Raman laser, UV-Vis., H-1-NMR spectra, X-ray powder diffraction, scanning electron microscopy and energy-dispersive X-ray spectroscopy (EDX). Upon the spectroscopic, conductivity and elemental analyses, the stoichiometric reactions indicated 1:2 (M:L) for Ca2+, Sr2+ and Ba2+ complexes [Ca(Adr)(2)(H2O)(2)](H2O)(4)Cl-2, [Sr(Adr)(2)(H2O)(2)]Cl-2 and [Ba(Adr)(2)(H2O)(6)]Cl-2 while the molar ratio of 1:1 (M:L) for Mg2+ with a formula [Mg-2(Adr)(2)(H2O)(7)]Cl-4. The interpretation of Raman and infrared spectra confirmed the coordination mode, which was through the two-catechol moiety OH phenolic groups. The in vitro antibacterial activity of adrenaline chelates that have been tested against three gram-positive bacteria, two gram-negative bacteria, and two strains of fungus showed that antimicrobial activity of the metal chelates are more effective than the adrenaline free ligand.

Automated summary

Adrenaline complexes with bivalent ions Mg2+, Ca2+, Sr2+ and Ba2+ in methanol at 60 degrees C were prepared and characterized. The stoichiometric reactions indicated different ratios for the complexes, with Ca2+, Sr2+ and Ba2+ having a ratio of 1:2 (M:L) and Mg2+ having a ratio of 1:1 (M:L). Spectroscopic analysis confirmed the coordination mode through the OH phenolic groups. The metal chelates of adrenaline showed higher antimicrobial activity compared to the free ligand.