Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 174, Issue 2, Pages 205-209Publisher
SPRINGER
DOI: 10.1007/s10517-023-05674-9
Keywords
liver cirrhosis; age-related features; hepatocytes; membrane microviscosity; ketanserin
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The effect of ketanserin on inflammation, liver fibrosis, and microviscosity of the plasma and mitochondrial membranes of hepatocytes was studied on young and old male Wistar rats with experimental liver cirrhosis. Ketanserin reduced inflammation, area of connective tissue, and liver damage and improved serum biochemical parameters. In old rats, ketanserin had more pronounced effects, reducing the polarity of hepatocyte membranes and increasing effectiveness in treating liver cirrhosis.
The effect of ketanserin on inflammation, liver fibrosis, and microviscosity of the plasma and mitochondrial membranes of hepatocytes was studied on young (3 months) and old (9 months) male Wistar rats with experimental liver cirrhosis. Ketanserin reduced inflammation, area of the connective tissue, and liver damage and improved serum biochemical parameters in rats of both age groups; in old rats, the effects were more pronounced than in young animals. In old rats, ketanserin reduced polarity of hepatocyte plasma and mitochondrial membranes in the area of protein-lipid contacts, which determined higher effectiveness of ketanserin during the treatment of liver cirrhosis in aged animals.
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