4.6 Letter

Frailty subgroup analysis of isatuximab with pomalidomide and dexamethasone in a UK-wide real-world cohort of relapsed myeloma patients

Related references

Note: Only part of the references are listed.
Article Hematology

Infections in relapsed myeloma patients treated with isatuximab plus pomalidomide and dexamethasone during the COVID-19 pandemic: Initial results of a UK-wide real-world study

Faouzi Djebbari et al.

Summary: This study retrospectively evaluated the infection morbidity in relapsed/refractory myeloma patients treated with anti-CD38 isatuximab in combination with pomalidomide and dexamethasone during the COVID-19 pandemic. Results showed that approximately 23.4% of patients experienced any grade (G2-5) infections and approximately 18.7% of patients experienced high grade (>= G3) infections after a median of 4 cycles of treatment. Higher comorbidity burden and sub-optimal myeloma response were associated with increased risk of infections.

HEMATOLOGY (2022)

Article Hematology

Isatuximab as monotherapy and combined with dexamethasone in patients with relapsed/refractory multiple myeloma

Meletios Dimopoulos et al.

Summary: This phase 2 study evaluated isatuximab as monotherapy or in combination with dexamethasone in relapsed/refractory multiple myeloma patients. The addition of dexamethasone to isatuximab increased response rates and survival outcomes with no detrimental effect on safety, providing a potentially more effective treatment option for these patients.

BLOOD (2021)