4.7 Article

Interplay between activation of endogenous retroviruses and inflammation as common pathogenic mechanism in neurological and psychiatric disorders

Related references

Note: Only part of the references are listed.
Article Immunology

Inflammatory Subtypes in Antipsychotic-Naive First-Episode Schizophrenia are Associated with Altered Brain Morphology and Topological Organization

Dung Hoang et al.

Summary: Inflammation plays a role in schizophrenia, and different inflammatory subtypes exist in antipsychotic-naive First-Episode Schizophrenia (FES) patients, with implications for cortical expansion. Identifying these inflammatory subtypes may offer a new direction for inflammation-related treatment in FES patients.

BRAIN BEHAVIOR AND IMMUNITY (2022)

Article Multidisciplinary Sciences

Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM

Tobias Lanz et al.

Summary: Multiple sclerosis (MS) is an autoimmune disease where autoreactive lymphocytes attack the central nervous system. Epstein-Barr virus (EBV) infection has been linked to MS, with molecular mimicry between EBV nuclear antigen 1 (EBNA1) and central nervous system protein GlialCAM. EBNA1 immunization exacerbates disease in MS mouse models and anti-EBNA1 and anti-GlialCAM antibodies are prevalent in MS patients, providing a mechanistic link between MS and EBV and guiding the development of new MS therapies.

NATURE (2022)

Article Cell Biology

Histone variant H3.3 maintains adult haematopoietic stem cell homeostasis by enforcing chromatin adaptability

Peipei Guo et al.

Summary: Guo et al. demonstrate that H3.3 prevents premature exhaustion and differentiation of HSCs by safeguarding the interplay between H3K27me3 and H3K9me3 marks. This maintenance of the delicate chromatin adaptability ensures the stemness of adult HSCs.

NATURE CELL BIOLOGY (2022)

Editorial Material Pharmacology & Pharmacy

Longitudinal Analysis Suggests Epstein--Barr as Cause of Multiple Sclerosis

[Anonymous]

CLINICAL PHARMACOLOGY & THERAPEUTICS (2022)

Article Clinical Neurology

Efficacy and safety of temelimab in multiple sclerosis: Results of a randomized phase 2b and extension study

Hans-Peter Hartung et al.

Summary: The study did not meet its primary endpoint, but at 48 weeks participants treated with 18 mg/kg temelimab had fewer new T1-hypointense lesions. They also showed consistent, although statistically non-significant, reductions in brain atrophy and magnetization transfer ratio decrease compared to the placebo/comparator group. These trends were sustained over 96 weeks with no safety issues emerging.

MULTIPLE SCLEROSIS JOURNAL (2022)

Article Behavioral Sciences

Male sex bias in early and late onset neurodevelopmental disorders: Shared aspects and differences in Autism Spectrum Disorder, Attention Deficit/ hyperactivity Disorder, and Schizophrenia

Sofia Santos et al.

Summary: Neurodevelopmental disorders have an early onset and result in social and communication impairments as well as cognitive deficits. The importance of biological sex in determining behavioral and cognitive vulnerability has been confirmed, impacting diagnosis and therapeutic response. Male bias exists to varying extents in autism spectrum disorder, attention deficit/hyperactivity disorder, and schizophrenia. Genetic predisposition, endocrine factors, and environmental factors interact to influence the onset, progression, and severity of the disorders.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2022)

Article Multidisciplinary Sciences

Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis

Kjetil Bjornevik et al.

Summary: This study suggests that multiple sclerosis may be caused by Epstein-Barr virus, with no direct association with other viral infections. These findings provide clues to the primary cause of MS.

SCIENCE (2022)

Article Biochemistry & Molecular Biology

Increased levels of midbrain immune-related transcripts in schizophrenia and in murine offspring after maternal immune activation

Tertia D. Purves-Tyson et al.

Summary: The research indicates that immune-related changes in the dopaminergic areas of the midbrain of schizophrenia patients are associated with a subgroup showing high immune status. The study also suggests that maternal immune activation (MIA) may be one of the contributing factors underlying persistent neuroimmune changes in the midbrain of people with schizophrenia.

MOLECULAR PSYCHIATRY (2021)

Article Cell Biology

Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation

Julia P. Gerber et al.

Summary: The study reveals that the H3.3 chaperone Daxx acts as an epigenetic barrier to control haematopoietic progenitor plasticity and protect against PU.1-mediated inflammation by repressing endogenous retroviral and retrotransposable elements. Defective silencing of these elements has been linked to inflammageing, cancer, and autoimmune diseases, implicating a potential role for Daxx in protection from inflammatory diseases.

NATURE CELL BIOLOGY (2021)

Article Clinical Neurology

Inhibition of HERV-K (HML-2) in amyotrophic lateral sclerosis patients on antiretroviral therapy

M. Garcia-Montojo et al.

Summary: The study found that a 24-week antiretroviral combination therapy in ALS patients can effectively inhibit HML-2 levels, with a majority of participants experiencing a decrease in HML-2 after treatment. Participants with a virological response to treatment showed a trend for slower progression of the illness.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2021)

Review Cell & Tissue Engineering

The Regulation and Functions of Endogenous Retrovirus in Embryo Development and Stem Cell Differentiation

Yangquan Xiang et al.

Summary: Endogenous retroviruses (ERVs) are repetitive sequences in the genome that play important roles in chromatin and transcriptional regulation during development and pathological conditions. In mammalian embryos, ERVs are activated in early development but silenced during differentiation, leading to questions about their regulation and functional importance. The dynamic activation pattern of ERVs suggests they are actively regulated during mammalian development and stem cell differentiation.

STEM CELLS INTERNATIONAL (2021)

Review Neurosciences

Viruses and Endogenous Retroviruses as Roots for Neuroinflammation and Neurodegenerative Diseases

Christine Roemer

Summary: Many neurodegenerative diseases are linked to chronic inflammation in the brain and periphery, with activation of transposable elements and endogenous retroviruses playing a role in disease progression. Endogenous retroviruses are remnants of viral infections in the human genome, producing transcripts upon activation and potentially triggering neuroinflammation.

FRONTIERS IN NEUROSCIENCE (2021)

Article Neurosciences

TLR4 Associated Signaling Disrupters as a New Means to Overcome HERV-W Envelope-Mediated Myelination Deficits

Peter Goettle et al.

Summary: The research highlights that HERV-W ENV protein inhibits OPC maturation and remyelination, and improving TLR4 surface expression can rescue these deficits. Specific substances like C20 and L48H437 show promise in this process.

FRONTIERS IN CELLULAR NEUROSCIENCE (2021)

Article Immunology

Cumulative Roles for Epstein-Barr Virus, Human Endogenous Retroviruses, and Human Herpes Virus-6 in Driving an Inflammatory Cascade Underlying MS Pathogenesis

Ute-Christiane Meier et al.

Summary: Viral infections and aberrant immune responses play critical roles in driving localized neuroinflammation and neurodegeneration in multiple sclerosis (MS). Epstein-Barr virus (EBV) is considered to be a key player in MS pathogenesis, triggering localized inflammation near or within the central nervous system (CNS) through direct or indirect mechanisms involving B-cells, T-cells, cytokine-activated astrocytes and microglia cells damaging the myelin sheath of neurons. Genetic factors like HLA-DR2b may contribute to aberrant EBV antigen-presentation and autoimmune responses characteristic of MS.

FRONTIERS IN IMMUNOLOGY (2021)

Article Medicine, General & Internal

Evidence of the pathogenic HERV-W envelope expression in T lymphocytes in association with the respiratory outcome of COVID-19 patients

Emanuela Balestrieri et al.

Summary: The study analyzed the expression of HERV-W ENV in the blood of COVID-19 patients, finding that it was highly expressed in patients' leukocytes and correlated with markers of T-cell differentiation, exhaustion, blood cytokine levels, inflammatory markers, and pneumonia severity. HERV-W ENV expression also reflected the respiratory outcome of patients during hospitalization, suggesting its potential as a biomarker for predicting disease progression and as a target for further therapeutic interventions.

EBIOMEDICINE (2021)

Article Medicine, Research & Experimental

Monocyte-released HERV-K dUTPase engages TLR4 and MCAM causing endothelial mesenchymal transition

Shoichiro Otsuki et al.

Summary: Research has shown that in patients with pulmonary arterial hypertension, monocytes and pulmonary arterial adventitial macrophages can release HERV-K dUTPase, leading to pulmonary arterial hypertension. HERV-K dUTPase interacts with multiple receptors and signaling pathways to affect endothelial cell transcriptional machinery, inducing endothelial mesenchymal transition and inflammatory molecules.

JCI INSIGHT (2021)

Review Immunology

Epigenetic lifestyle of Epstein-Barr virus

Alexander Buschle et al.

SEMINARS IN IMMUNOPATHOLOGY (2020)

Review Microbiology

Epigenetic and epitranscriptomic regulation of viral replication

Kevin Tsai et al.

NATURE REVIEWS MICROBIOLOGY (2020)

Article Biochemistry & Molecular Biology

Formation of HERV-K and HERV-Fc1 Envelope Family Members is Suppressed on Transcriptional and Translational Level

Victoria Groeger et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Critical Care Medicine

Dynamic LTR retrotransposon transcriptome landscape in septic shock patients

Marine Mommert et al.

CRITICAL CARE (2020)

Review Clinical Neurology

Epidemiology of amyotrophic lateral sclerosis: an update of recent literature

Elisa Longinetti et al.

CURRENT OPINION IN NEUROLOGY (2019)

Article Multidisciplinary Sciences

pHERV-W envelope protein fuels microglial cell-dependent damage of myelinated axons in multiple sclerosis

David Kremer et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Review Clinical Neurology

Chronic inflammation in multiple sclerosis - seeing what was always there

Paul M. Matthews

NATURE REVIEWS NEUROLOGY (2019)

Review Biochemistry & Molecular Biology

Endogenous Retroviruses Activity as a Molecular Signature of Neurodevelopmental Disorders

Emanuela Balestrieri et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Multidisciplinary Sciences

Transcription of human endogenous retroviruses in human brain by RNA-seq analysis

Fang Li et al.

PLOS ONE (2019)

Article Biochemistry & Molecular Biology

Switching roles for DNA and histone methylation depend on evolutionary ages of human endogenous retroviruses

Hitoshi Ohtani et al.

GENOME RESEARCH (2018)

Review Biochemistry & Molecular Biology

Human Endogenous Retroviruses in Neurological Diseases

Patrick Kuery et al.

TRENDS IN MOLECULAR MEDICINE (2018)

Review Neurosciences

The Emerging Neurobiology of Bipolar Disorder

Paul J. Harrison et al.

TRENDS IN NEUROSCIENCES (2018)

Review Psychiatry

Maternal Immune Activation and Neuropsychiatric Illness: A Translational Research Perspective

Alan S. Brown et al.

AMERICAN JOURNAL OF PSYCHIATRY (2018)

Review Virology

Nomenclature for endogenous retrovirus (ERV) loci

Robert J. Gifford et al.

RETROVIROLOGY (2018)

Article Biochemistry & Molecular Biology

LTRs activated by Epstein-Barr virus-induced transformation of B cells alter the transcriptome

Amy Leung et al.

GENOME RESEARCH (2018)

Article Biochemistry & Molecular Biology

The Decrease in Human Endogenous Retrovirus-H Activity Runs in Parallel with Improvement in ADHD Symptoms in Patients Undergoing Methylphenidate Therapy

Cipriani Chiara et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Genetics & Heredity

Variation in proviral content among human genomes mediated by LTR recombination

Jainy Thomas et al.

MOBILE DNA (2018)

Review Neurosciences

The Role of the Immune System in Autism Spectrum Disorder

Amory Meltzer et al.

NEUROPSYCHOPHARMACOLOGY (2017)

Article Multidisciplinary Sciences

KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks

Michael Imbeault et al.

NATURE (2017)

Review Cell Biology

Current view and perspectives in amyotrophic lateral sclerosis

Stephane Mathis et al.

NEURAL REGENERATION RESEARCH (2017)

Article Biochemistry & Molecular Biology

Hydroquinone induces DNA hypomethylation-independent overexpression of retroelements in human leukemia and hematopoietic stem cells

Anastasia Conti et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

Review Medicine, General & Internal

Schizophrenia

Michael J. Owen et al.

LANCET (2016)

Review Biochemistry & Molecular Biology

Long Terminal Repeats: From Parasitic Elements to Building Blocks of the Transcriptional Regulatory Repertoire

Peter J. Thompson et al.

MOLECULAR CELL (2016)

Review Biochemistry & Molecular Biology

Postmortem evidence of cerebral inflammation in schizophrenia: a systematic review

M. O. Trepanier et al.

MOLECULAR PSYCHIATRY (2016)

Article Multidisciplinary Sciences

Vitamin C increases viral mimicry induced by 5-aza-2′-deoxycytidine

Minmin Liu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Biochemical Research Methods

Integration and Fixation Preferences of Human and Mouse Endogenous Retroviruses Uncovered with Functional Data Analysis

Rebeca Campos-Sanchez et al.

PLOS COMPUTATIONAL BIOLOGY (2016)

Article Dermatology

DNA methylation modulates HERV-E expression in CD4+T cells from systemic lupus erythematosus patients

Zhouwei Wu et al.

JOURNAL OF DERMATOLOGICAL SCIENCE (2015)

Article Multidisciplinary Sciences

The histone methyltransferase SETDB1 represses endogenous and exogenous retroviruses in B lymphocytes

Patrick L. Collins et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Cell Biology

Human endogenous retrovirus-K contributes to motor neuron disease

Wenxue Li et al.

SCIENCE TRANSLATIONAL MEDICINE (2015)

Article Psychiatry

Human endogenous retroviruses and ADHD

Emanuela Balestrieri et al.

WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY (2014)

Article Public, Environmental & Occupational Health

Association between atopic diseases and attention-deficit/hyperactivity disorder in childhood: a population-based case-control study

Jeng-Dau Tsai et al.

ANNALS OF EPIDEMIOLOGY (2013)

Article Biochemistry & Molecular Biology

Increased inflammatory markers identified in the dorsolateral prefrontal cortex of individuals with schizophrenia

S. G. Fillman et al.

MOLECULAR PSYCHIATRY (2013)

Review Immunology

The role of immune dysfunction in the pathophysiology of autism

Charity Onore et al.

BRAIN BEHAVIOR AND IMMUNITY (2012)

Review Biochemistry & Molecular Biology

Silencing of endogenous retroviruses: when and why do histone marks predominate?

Danny C. Leung et al.

TRENDS IN BIOCHEMICAL SCIENCES (2012)

Article Biotechnology & Applied Microbiology

The genomic landscape shaped by selection on transposable elements across 18 mouse strains

Christoffer Nellaker et al.

GENOME BIOLOGY (2012)

Review Cell Biology

Regulation of chromatin by histone modifications

Andrew J. Bannister et al.

CELL RESEARCH (2011)

Article Biochemistry & Molecular Biology

Cell type-specific DNA methylation at intragenic CpG islands in the immune system

Aimee M. Deaton et al.

GENOME RESEARCH (2011)

Article Biochemistry & Molecular Biology

Coevolution of retroelements and tandem zinc finger genes

James H. Thomas et al.

GENOME RESEARCH (2011)

Article Oncology

Expression of human endogenous retrovirus K is stimulated by ultraviolet radiation in melanoma

Oliver Schanab et al.

PIGMENT CELL & MELANOMA RESEARCH (2011)

Review Virology

Viral Ancestors of Antiviral Systems

Luis P. Villarreal

VIRUSES-BASEL (2011)

Article Biotechnology & Applied Microbiology

Estimating enrichment of repetitive elements from high-throughput sequence data

Daniel S. Day et al.

GENOME BIOLOGY (2010)

Article Virology

Human herpesvirus-6B induces expression of the human endogenous retrovirus K18-encoded superantigen

Vanda Lauridsen Turcanova et al.

JOURNAL OF CLINICAL VIROLOGY (2009)

Article Virology

HHV-6A infection induces expression of HERV-K18-encoded superantigen

Albert K. Tai et al.

JOURNAL OF CLINICAL VIROLOGY (2009)

Review Biochemistry & Molecular Biology

Murine endogenous retroviruses

C. Stocking et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2008)

Article Multidisciplinary Sciences

A placenta-specific receptor for the fusogenic, endogenous retrovirus-derived, human syncytin-2

Cecile Esnault et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

Tarjei S. Mikkelsen et al.

NATURE (2007)

Article Immunology

Epigenetic regulation of Th1 and Th2 cell development

Virginia M. Sanders

BRAIN BEHAVIOR AND IMMUNITY (2006)

Article Biochemistry & Molecular Biology

Complete MHC haplotype disease gene mapping

CA Stewart et al.

GENOME RESEARCH (2004)

Review Biochemistry & Molecular Biology

New embo member's review -: NF-κB and virus infection:: who controls whom

MG Santoro et al.

EMBO JOURNAL (2003)

Article Multidisciplinary Sciences

Retroviral RNA identified in the cerebrospinal fluids and brains of individuals with schizophrenia

H Karlsson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Review Multidisciplinary Sciences

Initial sequencing and analysis of the human genome

ES Lander et al.

NATURE (2001)