Associations of white blood cell and platelet counts with specific depressive symptom dimensions in patients with bipolar disorder: Analysis of data from the FACE-BD cohort

Evidences suggest that inflammation is increased in a subgroup of patients with depression. Moreover, increased peripheral inflammatory markers (cells and proteins) are associated with some, but not all depressive symptoms. On the other hand, similar studies on bipolar disorders mainly focused on blood cytokines. Here, we analysed data from a large (N = 3440), well-characterized cohort of individuals with bipolar disorder using Kendall partial rank correlation, multivariate linear regression, and network analyses to determine whether peripheral blood cell counts are associated with depression severity, its symptoms, and dimensions. Based on the self-reported 16-Item Quick Inventory of Depressive Symptomatology questionnaire scores, we preselected symptom dimensions based

Automated summary

Studies suggest that inflammation is increased in some patients with depression, and peripheral inflammatory markers are associated with certain depressive symptoms. However, research on bipolar disorders mainly focuses on blood cytokines. In this study, data from a large cohort of individuals with bipolar disorder were analyzed to examine the association between peripheral blood cell counts and depression severity, symptoms, and dimensions.