SARS-CoV-2 targets pericytes to restrict blood flow within the brain

Article Clinical Neurology

SARS-CoV-2 triggers pericyte-mediated cerebral capillary constriction

Chanawee Hirunpattarasilp et al.

Summary: The binding of SARS-CoV-2 to ACE2 on capillary pericytes causes pericyte contraction and capillary constriction, leading to reduced blood flow in the brain, heart, and kidney. The drug losartan can prevent these effects.

BRAIN (2023)

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Article Biochemistry & Molecular Biology

Long-term neurologic outcomes of COVID-19

Evan Xu et al.

Summary: Individuals with COVID-19 have an increased risk of developing a range of neurologic disorders at 12 months, even if they were not hospitalized during the acute phase of the infection.

NATURE MEDICINE (2022)

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Article Neurosciences

What can we learn from brain autopsies in COVID-19?

Shibani S. Mukerji et al.

Summary: SARS-CoV-2 infection in causing COVID-19 can lead to a range of neurological symptoms, but the underlying mechanisms remain unclear, and the potential for neuroinvasion by the virus is uncertain. Human autopsies have revealed the neuropathological consequences of infection, and incorporating brain tissue research findings into our understanding of clinical disease will guide management and research priorities related to neurological morbidity.

NEUROSCIENCE LETTERS (2021)

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Article Immunology